Novel Mechanism of Fatty Acid Sensing in Enteroendocrine Cells: Specific Structures in Oxo‐Fatty Acids Produced by Gut Bacteria Are Responsible for CCK Secretion in STC‐1 Cells via GPR40

Scope The secretion of gut hormones, such as cholecystokinin (CCK) is stimulated by fatty acids. Although a chain length–dependent mechanism has been proposed, other structural relationships to releasing activity remain unclear. We aimed to elucidate specific structures in fatty acids that are respo...

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Veröffentlicht in:	Molecular nutrition & food research 2018-10, Vol.62 (19), p.e1800146-n/a
Hauptverfasser:	Hira, Tohru, Ogasawara, Shono, Yahagi, Asuka, Kamachi, Minami, Li, Jiaxin, Nishimura, Saki, Sakaino, Masayoshi, Yamashita, Takatoshi, Kishino, Shigenobu, Ogawa, Jun, Hara, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - pharmacokinetics Administration, Oral Animals Bacteria Cell Line Cholecystokinin Cholecystokinin - metabolism Cytotoxicity Detection Dosage Dose-Response Relationship, Drug Emptying enteroendocrine cells Enteroendocrine Cells - drug effects Enteroendocrine Cells - metabolism Fatty acids Fatty Acids - administration & dosage Fatty Acids - chemistry Fatty Acids - pharmacology Gastric emptying Gastric Emptying - drug effects Gastrointestinal Microbiome - physiology gut lactic acid bacteria metabolites Hormones Lactic acid Lactic acid bacteria Male Mice Oral administration Phenols Proteins Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - metabolism Secretion
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