Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma
Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined. SOX9 expression in surgical spec...
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| Veröffentlicht in: | In vivo (Athens) 2018-07, Vol.32 (4), p.835-838 |
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| container_title | In vivo (Athens) |
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| creator | Higo, Naotomo Okumura, Hiroshi Uchikado, Yasuto Omoto, Itaru Sasaki, Ken Kita, Yoshiaki Ryosuke, Desaki Noda, Masahiro Owaki, Tetsuhiro Ishigami, Sumiya Natsugoe, Shoji |
| description | Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined.
SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas.
SOX9 was expressed (moderately or strongly) in 62.9% of samples. Expression of SOX9 was significantly positively correlated with depth of invasion, advanced stage, lymphatic and venous invasion, and poor prognosis. Univariate analysis showed that depth of invasion, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, and SOX9 expression were prognostic factors. Multivariate analysis indicated that depth of invasion and stage were independent prognostic factors, but SOX9 expression was not.
SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor. |
| doi_str_mv | 10.21873/invivo.11316 |
| format | Article |
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SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas.
SOX9 was expressed (moderately or strongly) in 62.9% of samples. Expression of SOX9 was significantly positively correlated with depth of invasion, advanced stage, lymphatic and venous invasion, and poor prognosis. Univariate analysis showed that depth of invasion, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, and SOX9 expression were prognostic factors. Multivariate analysis indicated that depth of invasion and stage were independent prognostic factors, but SOX9 expression was not.
SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>DOI: 10.21873/invivo.11316</identifier><identifier>PMID: 29936467</identifier><language>eng</language><publisher>Greece</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - genetics ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - pathology ; Esophageal Squamous Cell Carcinoma ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Prognosis ; SOX9 Transcription Factor - genetics</subject><ispartof>In vivo (Athens), 2018-07, Vol.32 (4), p.835-838</ispartof><rights>Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-9bc4461190908defa870f190171d703a5686ae57755026ae04083179e034ca803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29936467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higo, Naotomo</creatorcontrib><creatorcontrib>Okumura, Hiroshi</creatorcontrib><creatorcontrib>Uchikado, Yasuto</creatorcontrib><creatorcontrib>Omoto, Itaru</creatorcontrib><creatorcontrib>Sasaki, Ken</creatorcontrib><creatorcontrib>Kita, Yoshiaki</creatorcontrib><creatorcontrib>Ryosuke, Desaki</creatorcontrib><creatorcontrib>Noda, Masahiro</creatorcontrib><creatorcontrib>Owaki, Tetsuhiro</creatorcontrib><creatorcontrib>Ishigami, Sumiya</creatorcontrib><creatorcontrib>Natsugoe, Shoji</creatorcontrib><title>Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined.
SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas.
SOX9 was expressed (moderately or strongly) in 62.9% of samples. Expression of SOX9 was significantly positively correlated with depth of invasion, advanced stage, lymphatic and venous invasion, and poor prognosis. Univariate analysis showed that depth of invasion, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, and SOX9 expression were prognostic factors. Multivariate analysis indicated that depth of invasion and stage were independent prognostic factors, but SOX9 expression was not.
SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Squamous Cell Carcinoma</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>SOX9 Transcription Factor - genetics</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1Lw0AQhhdRbK0evcoevaTOZr-PUvwoFFqsQm9hm2zalSSbZpOq_97QVk8zAw8v7zwI3RIYx0RJ-uCqvdv7MSGUiDM0JFKTSHKmz9EQYq4ixclqgK5C-AQQEiC-RINYayqYkEOUPH3XjQ3B-Qr7HC_nK42nAb_ZwrQ2w63Hi8ZvKh9cwK7CC9M6W7UBf7l2i-c2-HprNtYUeLnrTOm7gCe2KPDENKmrfGmu0UVuimBvTnOEPp6f3iev0Wz-Mp08zqKU0riN9DplTBCiQYPKbG6UhLy_iCSZBGq4UMJYLiXnEPcbMFC0f9UCZalRQEfo_phbN37X2dAmpQtpX8VUtm-VxMA1MEYE79HoiKaND6GxeVI3rjTNT0IgOThNjk6Tg9OevztFd-vSZv_0n0T6C1bychM</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Higo, Naotomo</creator><creator>Okumura, Hiroshi</creator><creator>Uchikado, Yasuto</creator><creator>Omoto, Itaru</creator><creator>Sasaki, Ken</creator><creator>Kita, Yoshiaki</creator><creator>Ryosuke, Desaki</creator><creator>Noda, Masahiro</creator><creator>Owaki, Tetsuhiro</creator><creator>Ishigami, Sumiya</creator><creator>Natsugoe, Shoji</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180701</creationdate><title>Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma</title><author>Higo, Naotomo ; Okumura, Hiroshi ; Uchikado, Yasuto ; Omoto, Itaru ; Sasaki, Ken ; Kita, Yoshiaki ; Ryosuke, Desaki ; Noda, Masahiro ; Owaki, Tetsuhiro ; Ishigami, Sumiya ; Natsugoe, Shoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-9bc4461190908defa870f190171d703a5686ae57755026ae04083179e034ca803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Squamous Cell Carcinoma</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>SOX9 Transcription Factor - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higo, Naotomo</creatorcontrib><creatorcontrib>Okumura, Hiroshi</creatorcontrib><creatorcontrib>Uchikado, Yasuto</creatorcontrib><creatorcontrib>Omoto, Itaru</creatorcontrib><creatorcontrib>Sasaki, Ken</creatorcontrib><creatorcontrib>Kita, Yoshiaki</creatorcontrib><creatorcontrib>Ryosuke, Desaki</creatorcontrib><creatorcontrib>Noda, Masahiro</creatorcontrib><creatorcontrib>Owaki, Tetsuhiro</creatorcontrib><creatorcontrib>Ishigami, Sumiya</creatorcontrib><creatorcontrib>Natsugoe, Shoji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higo, Naotomo</au><au>Okumura, Hiroshi</au><au>Uchikado, Yasuto</au><au>Omoto, Itaru</au><au>Sasaki, Ken</au><au>Kita, Yoshiaki</au><au>Ryosuke, Desaki</au><au>Noda, Masahiro</au><au>Owaki, Tetsuhiro</au><au>Ishigami, Sumiya</au><au>Natsugoe, Shoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>32</volume><issue>4</issue><spage>835</spage><epage>838</epage><pages>835-838</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined.
SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas.
SOX9 was expressed (moderately or strongly) in 62.9% of samples. Expression of SOX9 was significantly positively correlated with depth of invasion, advanced stage, lymphatic and venous invasion, and poor prognosis. Univariate analysis showed that depth of invasion, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, and SOX9 expression were prognostic factors. Multivariate analysis indicated that depth of invasion and stage were independent prognostic factors, but SOX9 expression was not.
SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor.</abstract><cop>Greece</cop><pmid>29936467</pmid><doi>10.21873/invivo.11316</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aged Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Female Gene Expression Regulation, Neoplastic Humans Lymph Nodes - pathology Lymphatic Metastasis Male Middle Aged Prognosis SOX9 Transcription Factor - genetics |
| title | Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma |
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