Intestinal barrier disruption and dysregulated mucosal immunity contribute to kidney fibrosis in chronic kidney disease

Abstract Background Emerging evidence suggests that intestinal dysbiosis is associated with diverse pathological processes. In this study we demonstrated intestinal barrier disruption and aberrant mucosal immunity in 5/6 nephrectomized mice and the effect of probiotics on chronic kidney disease (CKD...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2019-03, Vol.34 (3), p.419-428
Hauptverfasser:	Yang, Jihyun, Lim, Sung Yoon, Ko, Yoon Sook, Lee, Hee Young, Oh, Se Won, Kim, Myung Gyu, Cho, Won Yong, Jo, Sang Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane Permeability Colon - pathology Dysbiosis - physiopathology Fibrosis - etiology Fibrosis - pathology Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - immunology Immunity, Mucosal - immunology Intestines - pathology Male Mice Mice, Inbred C57BL Probiotics - administration & dosage Renal Insufficiency, Chronic - complications
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