Tissue-resident stem cells promote breast cancer growth and metastasis

Mesenchymal stem cells derived from bone marrow have recently been described to localize to breast carcinomas and to integrate into the tumor-associated stroma. In the present study, we investigated whether adipose tissue-derived stem cells (ASCs) could play a role in tumor growth and invasion. Comp...

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Veröffentlicht in:	Carcinogenesis (New York) 2009-04, Vol.30 (4), p.589-597
Hauptverfasser:	Muehlberg, Fabian L., Song, Yao-Hua, Krohn, Alexander, Pinilla, Severin P., Droll, Lilly H., Leng, Xiaohong, Seidensticker, Max, Ricke, Jens, Altman, Andrew M., Devarajan, Eswaran, Liu, Weili, Arlinghaus, Ralph B., Alt, Eckhard U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adipose Tissue - pathology Animals Biological and medical sciences Blotting, Western Breast cancer Carcinogenesis, carcinogens and anticarcinogens Cell Movement Chemokine CXCL12 - metabolism Enzyme-Linked Immunosorbent Assay Flow Cytometry Gynecology. Andrology. Obstetrics Immunoprecipitation Lung Neoplasms - metabolism Lung Neoplasms - secondary Male Mammary gland diseases Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - pathology Medical sciences Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness Neoplastic Stem Cells - metabolism Neovascularization, Pathologic Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Spheroids, Cellular Stromal Cells - cytology Stromal Cells - metabolism Tumors Vascular Endothelial Growth Factor A - metabolism
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