A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis

Objective A lack of published pharmacokinetic data on statins in sepsis has prompted concerns about their safety and toxicity. This study determined single dose pharmacokinetics of Atorvastatin administered orally to acutely ill patients. Design, setting and participants A prospective open label stu...

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Veröffentlicht in:	Intensive care medicine 2009-04, Vol.35 (4), p.717-721
Hauptverfasser:	Kruger, Peter S., Freir, Noelle M., Venkatesh, Bala, Robertson, Thomas A., Roberts, Michael S., Jones, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Anticholesteremic Agents - blood Anticholesteremic Agents - pharmacokinetics APACHE Atorvastatin Calcium Biological and medical sciences Brief Report Chromatography, High Pressure Liquid Critical Care Critical Care Medicine Emergency and intensive care: infection, septic shock Emergency Medicine Female Heptanoic Acids - blood Heptanoic Acids - pharmacokinetics Humans Intensive Intensive care Intensive care medicine Male Medical sciences Medicine Medicine & Public Health Metabolism Pain Medicine Patients Pediatrics Pharmacokinetics Plasma Pneumology/Respiratory System Prospective Studies Pyrroles - blood Pyrroles - pharmacokinetics Sepsis Sepsis - blood Statins Toxicity
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