B cells behaving badly
Summary The pathogenesis of B‐cell lymphoproliferative disorders in general and B‐cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either compone...
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| Veröffentlicht in: | British journal of haematology 2007-12, Vol.139 (5), p.658-662 |
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| container_title | British journal of haematology |
| container_volume | 139 |
| creator | Shim, Youn K. Silver, Sharon R. Caporaso, Neil E. Marti, Gerald E. Middleton, Dannie C. Linet, Martha S. Vogt, Robert F. |
| description | Summary
The pathogenesis of B‐cell lymphoproliferative disorders in general and B‐cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure‐disease continuum, monoclonal B‐cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled ‘Monoclonal B‐cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors’. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan. |
| doi_str_mv | 10.1111/j.1365-2141.2007.06842.x |
| format | Article |
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The pathogenesis of B‐cell lymphoproliferative disorders in general and B‐cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure‐disease continuum, monoclonal B‐cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled ‘Monoclonal B‐cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors’. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2007.06842.x</identifier><identifier>PMID: 18021079</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>aetiology ; Biological and medical sciences ; chronic lymphocytic leukaemia ; Genetic Predisposition to Disease ; genetics ; Hematologic and hematopoietic diseases ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell - etiology ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytosis - etiology ; Medical sciences ; monoclonal B‐cell lymphocytosis ; Paraproteinemias - etiology ; Precancerous Conditions - etiology ; Risk Factors</subject><ispartof>British journal of haematology, 2007-12, Vol.139 (5), p.658-662</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4782-3de011a16d06202329dfe6a908cbb5b64525e9639c548481990caf3d1fcdbb4f3</citedby><cites>FETCH-LOGICAL-c4782-3de011a16d06202329dfe6a908cbb5b64525e9639c548481990caf3d1fcdbb4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2007.06842.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2007.06842.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,1435,27931,27932,45581,45582,46416,46840</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19869114$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18021079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shim, Youn K.</creatorcontrib><creatorcontrib>Silver, Sharon R.</creatorcontrib><creatorcontrib>Caporaso, Neil E.</creatorcontrib><creatorcontrib>Marti, Gerald E.</creatorcontrib><creatorcontrib>Middleton, Dannie C.</creatorcontrib><creatorcontrib>Linet, Martha S.</creatorcontrib><creatorcontrib>Vogt, Robert F.</creatorcontrib><creatorcontrib>for the 2007 International CLL/MBL Workshop</creatorcontrib><title>B cells behaving badly</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
The pathogenesis of B‐cell lymphoproliferative disorders in general and B‐cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure‐disease continuum, monoclonal B‐cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled ‘Monoclonal B‐cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors’. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan.</description><subject>aetiology</subject><subject>Biological and medical sciences</subject><subject>chronic lymphocytic leukaemia</subject><subject>Genetic Predisposition to Disease</subject><subject>genetics</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - etiology</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocytosis - etiology</subject><subject>Medical sciences</subject><subject>monoclonal B‐cell lymphocytosis</subject><subject>Paraproteinemias - etiology</subject><subject>Precancerous Conditions - etiology</subject><subject>Risk Factors</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkD1PwzAQhi0EoqWwMqIssCXc2Y5jDwy0AgqqxAKzZTsOpEo_iAm0_56ERnTlljvpfe7rJSRCSLCN63mCTKQxRY4JBcgSEJLTZHNAhn_CIRlCK8UIXA7ISQhzAGSQ4jEZoASKkKkhOR9HzldViKx_N1_l8i2yJq-2p-SoMFXwZ30ekdf7u5fJNJ49PzxObmex45mkMcs9IBoUOQgKlFGVF14YBdJZm1rBU5p6JZhyKZdcolLgTMFyLFxuLS_YiFzt5q7r1Ufjw6delKE7yCz9qgmaQioFp1kLyh3o6lUItS_0ui4Xpt5qBN15oue6e113r-vOE_3rid60rRf9jsYufL5v7E1ogcseMMGZqqjN0pVhzykpFCJvuZsd911WfvvvA_T4adpV7Ad4znmD</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Shim, Youn K.</creator><creator>Silver, Sharon R.</creator><creator>Caporaso, Neil E.</creator><creator>Marti, Gerald E.</creator><creator>Middleton, Dannie C.</creator><creator>Linet, Martha S.</creator><creator>Vogt, Robert F.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200712</creationdate><title>B cells behaving badly</title><author>Shim, Youn K. ; Silver, Sharon R. ; Caporaso, Neil E. ; Marti, Gerald E. ; Middleton, Dannie C. ; Linet, Martha S. ; Vogt, Robert F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4782-3de011a16d06202329dfe6a908cbb5b64525e9639c548481990caf3d1fcdbb4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>aetiology</topic><topic>Biological and medical sciences</topic><topic>chronic lymphocytic leukaemia</topic><topic>Genetic Predisposition to Disease</topic><topic>genetics</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - etiology</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocytosis - etiology</topic><topic>Medical sciences</topic><topic>monoclonal B‐cell lymphocytosis</topic><topic>Paraproteinemias - etiology</topic><topic>Precancerous Conditions - etiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shim, Youn K.</creatorcontrib><creatorcontrib>Silver, Sharon R.</creatorcontrib><creatorcontrib>Caporaso, Neil E.</creatorcontrib><creatorcontrib>Marti, Gerald E.</creatorcontrib><creatorcontrib>Middleton, Dannie C.</creatorcontrib><creatorcontrib>Linet, Martha S.</creatorcontrib><creatorcontrib>Vogt, Robert F.</creatorcontrib><creatorcontrib>for the 2007 International CLL/MBL Workshop</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shim, Youn K.</au><au>Silver, Sharon R.</au><au>Caporaso, Neil E.</au><au>Marti, Gerald E.</au><au>Middleton, Dannie C.</au><au>Linet, Martha S.</au><au>Vogt, Robert F.</au><aucorp>for the 2007 International CLL/MBL Workshop</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B cells behaving badly</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2007-12</date><risdate>2007</risdate><volume>139</volume><issue>5</issue><spage>658</spage><epage>662</epage><pages>658-662</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
The pathogenesis of B‐cell lymphoproliferative disorders in general and B‐cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure‐disease continuum, monoclonal B‐cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled ‘Monoclonal B‐cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors’. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18021079</pmid><doi>10.1111/j.1365-2141.2007.06842.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | aetiology Biological and medical sciences chronic lymphocytic leukaemia Genetic Predisposition to Disease genetics Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - etiology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytosis - etiology Medical sciences monoclonal B‐cell lymphocytosis Paraproteinemias - etiology Precancerous Conditions - etiology Risk Factors |
| title | B cells behaving badly |
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