bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

Broad aspects of Caenorhabditis elegans life history, including larval developmental timing, arrest at the dauer diapause, and longevity, are regulated by the nuclear receptor DAF-12. Endogenous DAF-12 ligands are 3-keto bile acid-like steroids, called dafachronic acids, which rescue larval defects...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-03, Vol.104 (12), p.5014-5019
Hauptverfasser:	Gerisch, Birgit, Rottiers, Veerle, Li, Dongling, Motola, Daniel L, Cummins, Carolyn L, Lehrach, Hans, Mangelsdorf, David J, Antebi, Adam
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - drug effects Aging Animals Bile Bile acids Bile Acids and Salts - pharmacology Biological Sciences Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - metabolism Cell Nucleus - drug effects Cytochrome P-450 Enzyme System - metabolism Genetics Germ Cells - drug effects Heat tolerance Hormonal regulation Hormones Intestines - drug effects Invertebrate Hormones - pharmacology Larva - drug effects Larval development Ligands Longevity Longevity - drug effects Molecular biology Nematode larvae Oxidative stress Receptors, Cytoplasmic and Nuclear - metabolism Recombinant Fusion Proteins - metabolism Signal Transduction - drug effects Steroids Stress tolerance Temperature
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