Gender-related differences in pharmacokinetics, tissue distribution, and excretion of 20(R)-25-methoxyl-dammarane-3β,12β,20-triol and its metabolite in rats and anti-ovarian cancer evaluation

[Display omitted] •A sensitive and specific UPLC-MS/MS method was established and validated for simultaneous quantification of 20(R)-25-methoxyl-dammarane-3β,12β,20-triol (AD-1) and its metabolite AD-2 in rat tissues, urine, feces, and bile.•Gender-related differences were found in pharmacokinetics,...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2018-09, Vol.158, p.327-338
Hauptverfasser:	Ding, Meng, Zhang, Yumeng, Wang, Xude, Zhao, Yuqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Excretion Gender-related differences Ovarian cancer Pharmacokinetics Tissue distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!