β-Thalassemia heterozygote state detrimentally affects health expectation
Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state. A total of 26,006 individuals seeking thalas...
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| Veröffentlicht in: | European journal of internal medicine 2018-08, Vol.54, p.76-80 |
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| creator | Graffeo, Luciano Vitrano, Angela Scondotto, Salvatore Dardanoni, Gabriella Pollina Addario, Walter Sebastiano Giambona, Antonino Sacco, Massimiliano Di Maggio, Rosario Renda, Disma Taormina, Federico Triveri, Andrea Attanasio, Massimo Gluud, Christian Maggio, Aurelio |
| description | Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied.
The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state.
A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality.
We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p |
| doi_str_mv | 10.1016/j.ejim.2018.06.009 |
| format | Article |
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The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state.
A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality.
We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p = .426).
This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.
•β-Thalassemia heterozygote state detrimentally affects health expectation.•Risk of hospitalizations for cholelithiasis, cirrhosis, mood disorders, and kidney diseases•Increased risk for complications in Thalassemia minor subjects•Increased morbiduty in heterozygotes for beta-thalassemia•Impaired morbidity in Thalassemia minor</description><identifier>ISSN: 0953-6205</identifier><identifier>EISSN: 1879-0828</identifier><identifier>DOI: 10.1016/j.ejim.2018.06.009</identifier><identifier>PMID: 29934240</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>beta-Thalassemia - genetics ; beta-Thalassemia - mortality ; Cholelithiasis - complications ; Health expectation ; Heterozygote ; Hospitalization ; Humans ; Italy ; Kidney Diseases - complications ; Life Expectancy ; Liver Cirrhosis - complications ; Logistic Models ; Mood Disorders - complications ; Mortality ; Thalassemia minor ; β-Thalassemia carrier state</subject><ispartof>European journal of internal medicine, 2018-08, Vol.54, p.76-80</ispartof><rights>2018 European Federation of Internal Medicine</rights><rights>Copyright © 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-95e508195e6804caed06cb9a687477535f0ba102a97e56d94bb0dc53ef8eddc23</citedby><cites>FETCH-LOGICAL-c356t-95e508195e6804caed06cb9a687477535f0ba102a97e56d94bb0dc53ef8eddc23</cites><orcidid>0000-0002-1037-1767</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejim.2018.06.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29934240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graffeo, Luciano</creatorcontrib><creatorcontrib>Vitrano, Angela</creatorcontrib><creatorcontrib>Scondotto, Salvatore</creatorcontrib><creatorcontrib>Dardanoni, Gabriella</creatorcontrib><creatorcontrib>Pollina Addario, Walter Sebastiano</creatorcontrib><creatorcontrib>Giambona, Antonino</creatorcontrib><creatorcontrib>Sacco, Massimiliano</creatorcontrib><creatorcontrib>Di Maggio, Rosario</creatorcontrib><creatorcontrib>Renda, Disma</creatorcontrib><creatorcontrib>Taormina, Federico</creatorcontrib><creatorcontrib>Triveri, Andrea</creatorcontrib><creatorcontrib>Attanasio, Massimo</creatorcontrib><creatorcontrib>Gluud, Christian</creatorcontrib><creatorcontrib>Maggio, Aurelio</creatorcontrib><title>β-Thalassemia heterozygote state detrimentally affects health expectation</title><title>European journal of internal medicine</title><addtitle>Eur J Intern Med</addtitle><description>Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied.
The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state.
A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality.
We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p = .426).
This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.
•β-Thalassemia heterozygote state detrimentally affects health expectation.•Risk of hospitalizations for cholelithiasis, cirrhosis, mood disorders, and kidney diseases•Increased risk for complications in Thalassemia minor subjects•Increased morbiduty in heterozygotes for beta-thalassemia•Impaired morbidity in Thalassemia minor</description><subject>beta-Thalassemia - genetics</subject><subject>beta-Thalassemia - mortality</subject><subject>Cholelithiasis - complications</subject><subject>Health expectation</subject><subject>Heterozygote</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Italy</subject><subject>Kidney Diseases - complications</subject><subject>Life Expectancy</subject><subject>Liver Cirrhosis - complications</subject><subject>Logistic Models</subject><subject>Mood Disorders - complications</subject><subject>Mortality</subject><subject>Thalassemia minor</subject><subject>β-Thalassemia carrier state</subject><issn>0953-6205</issn><issn>1879-0828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EouXxAyxQl2wSxk7s2BIbhHgKiQ2sLceeUFdJU2IXUT6LD-GbcNXCks2MRjpzpXsIOaGQU6DifJbjzHc5AypzEDmA2iFjKiuVgWRyl4xB8SITDPiIHIQwA6AVQLFPRkypomQljMnD91f2PDWtCQE7byZTjDj0n6vXPuIkRJOmwzj4DufRtO1qYpoGbQwJNG2cTvBjkU4TfT8_InuNaQMeb_chebm5fr66yx6fbu-vLh8zW3ARM8WRg6RpCQmlNehA2FoZIauyqnjBG6gNBWZUhVw4VdY1OMsLbCQ6Z1lxSM42uYuhf1tiiLrzwWLbmjn2y6BTX8mhYpwnlG1QO_QhDNjoRapihpWmoNcO9UyvHeq1Qw1CJ4fp6XSbv6w7dH8vv9IScLEBMLV89zjoYD3OLTo_JBna9f6__B-AKISF</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Graffeo, Luciano</creator><creator>Vitrano, Angela</creator><creator>Scondotto, Salvatore</creator><creator>Dardanoni, Gabriella</creator><creator>Pollina Addario, Walter Sebastiano</creator><creator>Giambona, Antonino</creator><creator>Sacco, Massimiliano</creator><creator>Di Maggio, Rosario</creator><creator>Renda, Disma</creator><creator>Taormina, Federico</creator><creator>Triveri, Andrea</creator><creator>Attanasio, Massimo</creator><creator>Gluud, Christian</creator><creator>Maggio, Aurelio</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1037-1767</orcidid></search><sort><creationdate>201808</creationdate><title>β-Thalassemia heterozygote state detrimentally affects health expectation</title><author>Graffeo, Luciano ; Vitrano, Angela ; Scondotto, Salvatore ; Dardanoni, Gabriella ; Pollina Addario, Walter Sebastiano ; Giambona, Antonino ; Sacco, Massimiliano ; Di Maggio, Rosario ; Renda, Disma ; Taormina, Federico ; Triveri, Andrea ; Attanasio, Massimo ; Gluud, Christian ; Maggio, Aurelio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-95e508195e6804caed06cb9a687477535f0ba102a97e56d94bb0dc53ef8eddc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>beta-Thalassemia - genetics</topic><topic>beta-Thalassemia - mortality</topic><topic>Cholelithiasis - complications</topic><topic>Health expectation</topic><topic>Heterozygote</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Italy</topic><topic>Kidney Diseases - complications</topic><topic>Life Expectancy</topic><topic>Liver Cirrhosis - complications</topic><topic>Logistic Models</topic><topic>Mood Disorders - complications</topic><topic>Mortality</topic><topic>Thalassemia minor</topic><topic>β-Thalassemia carrier state</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graffeo, Luciano</creatorcontrib><creatorcontrib>Vitrano, Angela</creatorcontrib><creatorcontrib>Scondotto, Salvatore</creatorcontrib><creatorcontrib>Dardanoni, Gabriella</creatorcontrib><creatorcontrib>Pollina Addario, Walter Sebastiano</creatorcontrib><creatorcontrib>Giambona, Antonino</creatorcontrib><creatorcontrib>Sacco, Massimiliano</creatorcontrib><creatorcontrib>Di Maggio, Rosario</creatorcontrib><creatorcontrib>Renda, Disma</creatorcontrib><creatorcontrib>Taormina, Federico</creatorcontrib><creatorcontrib>Triveri, Andrea</creatorcontrib><creatorcontrib>Attanasio, Massimo</creatorcontrib><creatorcontrib>Gluud, Christian</creatorcontrib><creatorcontrib>Maggio, Aurelio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graffeo, Luciano</au><au>Vitrano, Angela</au><au>Scondotto, Salvatore</au><au>Dardanoni, Gabriella</au><au>Pollina Addario, Walter Sebastiano</au><au>Giambona, Antonino</au><au>Sacco, Massimiliano</au><au>Di Maggio, Rosario</au><au>Renda, Disma</au><au>Taormina, Federico</au><au>Triveri, Andrea</au><au>Attanasio, Massimo</au><au>Gluud, Christian</au><au>Maggio, Aurelio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>β-Thalassemia heterozygote state detrimentally affects health expectation</atitle><jtitle>European journal of internal medicine</jtitle><addtitle>Eur J Intern Med</addtitle><date>2018-08</date><risdate>2018</risdate><volume>54</volume><spage>76</spage><epage>80</epage><pages>76-80</pages><issn>0953-6205</issn><eissn>1879-0828</eissn><abstract>Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied.
The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state.
A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality.
We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p = .426).
This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.
•β-Thalassemia heterozygote state detrimentally affects health expectation.•Risk of hospitalizations for cholelithiasis, cirrhosis, mood disorders, and kidney diseases•Increased risk for complications in Thalassemia minor subjects•Increased morbiduty in heterozygotes for beta-thalassemia•Impaired morbidity in Thalassemia minor</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29934240</pmid><doi>10.1016/j.ejim.2018.06.009</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-1037-1767</orcidid></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | beta-Thalassemia - genetics beta-Thalassemia - mortality Cholelithiasis - complications Health expectation Heterozygote Hospitalization Humans Italy Kidney Diseases - complications Life Expectancy Liver Cirrhosis - complications Logistic Models Mood Disorders - complications Mortality Thalassemia minor β-Thalassemia carrier state |
| title | β-Thalassemia heterozygote state detrimentally affects health expectation |
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