Physicochemical and in vitro biological evaluations of furazolidone-based β-cyclodextrin complexes in Leishmania amazonensis

Recently, there have been numerous cases of leishmaniasis reported in different Brazilian states. The use of furazolidone (FZD) to treat leishmaniasis has been previously described; however, the drug is associated with adverse effects such as anorexia, weight loss, incoordination, and fatigue in dog...

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Veröffentlicht in:	Research in veterinary science 2018-08, Vol.119, p.143-153
Hauptverfasser:	Carvalho, Suzana Gonçalves, Siqueira, Larissa Ataíde, Zanini, Marcos Santos, dos Santos Matos, Ana Paula, Quaresma, Carla Holandino, da Silva, Luisa Mota, de Andrade, Sérgio Faloni, Severi, Juliana Aparecida, Villanova, Janaina Cecília Oliveira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anorexia Antileishmanial activity Antiprotozoal Agents - adverse effects Antiprotozoal Agents - pharmacology beta-Cyclodextrins - adverse effects beta-Cyclodextrins - pharmacology Bioavailability Brazil Complexation Cutaneous canine leishmaniasis Cyclodextrins Cytotoxicity Dogs Drug dosages Fatigue Freeze drying Furazolidone Furazolidone - adverse effects Furazolidone - pharmacology In vitro methods and tests Inclusion complex Inclusion complexes Leishmania mexicana - drug effects Leishmaniasis Molecular weight Parasites Parasitic diseases Parasitic Sensitivity Tests Pharmaceuticals Pharmacology Physicochemical analysis Promastigotes Solubility Studies Toxicity testing Treatment Outcome Tropical diseases Vector-borne diseases Veterinary medicine Weight β-Cyclodextrin
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