Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm

RATIONALE:ADAM17 (a disintegrin and metalloproteinase-17) is a membrane-bound enzyme that regulates bioavailability of multiple transmembrane proteins by proteolytic processing. ADAM17 has been linked to several pathologies, but its role in thoracic aortic aneurysm (TAA) has not been determined. OBJ...

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Veröffentlicht in:	Circulation research 2018-07, Vol.123 (3), p.372-388
Hauptverfasser:	Shen, Mengcheng, Hu, Mei, Fedak, Paul W.M, Oudit, Gavin Y, Kassiri, Zamaneh
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM protein Aneurysms Aorta Aortic aneurysms Bioavailability Cadherins Endothelial cells Fibrosis Membrane proteins Muscle contraction Phenotypes Proteinase Proteolysis siRNA Smooth muscle Thorax Tight junctions
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