Transmission of Unidirectional Molecular Motor Rotation to a Remote Biaryl Axis

Molecular motors undergo repetitive directional motions upon external energy input. A profound challenge is the defined transfer of directional motor motions to remote entities at the molecular scale. Herein, we present a molecular setup that allows for the transfer of the directional rotation of a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2018-08, Vol.57 (34), p.11064-11068
Hauptverfasser: Uhl, Edgar, Thumser, Stefan, Mayer, Peter, Dube, Henry
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 11068
container_issue 34
container_start_page 11064
container_title Angewandte Chemie International Edition
container_volume 57
creator Uhl, Edgar
Thumser, Stefan
Mayer, Peter
Dube, Henry
description Molecular motors undergo repetitive directional motions upon external energy input. A profound challenge is the defined transfer of directional motor motions to remote entities at the molecular scale. Herein, we present a molecular setup that allows for the transfer of the directional rotation of a light‐powered motor unit onto a remote biaryl axis via an ethylene glycol chain link. Based on a combination of X‐ray crystallographic analysis, ECD, and NMR experiments as well as a comprehensive theoretical assessment, we provide evidence for the coupled stepwise directional motions of both molecular units. With the presented setup, facile integration of molecular motor units into larger functional frameworks and complex molecular machines can be explored consciously in the future. Set into motion: The directional rotation of a hemithioindigo‐based molecular motor is effectively transmitted to a remote asymmetric biaryl axis via an ethylene glycol chain. With the presented setup, directional motions can now be relayed to other functional entities against the equilibrating Brownian motion on the molecular scale with high precision.
doi_str_mv 10.1002/anie.201804716
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2058503698</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2058503698</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4766-725a94b2bf10c5542f4f58984aa39c6cbc8ee12f91af7482ea78b0ab9620592b3</originalsourceid><addsrcrecordid>eNqFkEtLAzEURoMoVqtblxJw42ZqnpNkWUt9gFoo7XrIpBmITCc1mUH7783QWsGNq9xwz_3gOwBcYTTCCJE73Tg7IghLxATOj8AZ5gRnVAh6nGZGaSYkxwNwHuN74qVE-SkYEKUoYTI_A7NF0E1cuxidb6Cv4LJxKxesadNf1_DV19Z0tQ5pan2Ac9_qfgVbDzWc27VvLbx3OmxrOP5y8QKcVLqO9nL_DsHyYbqYPGUvs8fnyfglM0zkeSYI14qVpKwwMpwzUrGKSyWZ1lSZ3JRGWotJpbCuBJPEaiFLpEuVE8QVKekQ3O5yN8F_dDa2RepgbF3rxvouFgmTHNFcyYTe_EHffRdSuZ6SglOOko4hGO0oE3yMwVbFJrh16lVgVPSqi151cVCdDq73sV25tqsD_uM2AWoHfLrabv-JK8Zvz9Pf8G8FVYnX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2087535099</pqid></control><display><type>article</type><title>Transmission of Unidirectional Molecular Motor Rotation to a Remote Biaryl Axis</title><source>Wiley Online Library All Journals</source><creator>Uhl, Edgar ; Thumser, Stefan ; Mayer, Peter ; Dube, Henry</creator><creatorcontrib>Uhl, Edgar ; Thumser, Stefan ; Mayer, Peter ; Dube, Henry</creatorcontrib><description>Molecular motors undergo repetitive directional motions upon external energy input. A profound challenge is the defined transfer of directional motor motions to remote entities at the molecular scale. Herein, we present a molecular setup that allows for the transfer of the directional rotation of a light‐powered motor unit onto a remote biaryl axis via an ethylene glycol chain link. Based on a combination of X‐ray crystallographic analysis, ECD, and NMR experiments as well as a comprehensive theoretical assessment, we provide evidence for the coupled stepwise directional motions of both molecular units. With the presented setup, facile integration of molecular motor units into larger functional frameworks and complex molecular machines can be explored consciously in the future. Set into motion: The directional rotation of a hemithioindigo‐based molecular motor is effectively transmitted to a remote asymmetric biaryl axis via an ethylene glycol chain. With the presented setup, directional motions can now be relayed to other functional entities against the equilibrating Brownian motion on the molecular scale with high precision.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201804716</identifier><identifier>PMID: 29932486</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Crystallography ; Ethylene glycol ; hemithioindigo ; isomerization ; Molecular machines ; Molecular motors ; Motor units ; NMR ; Nuclear magnetic resonance ; photochemistry ; physical chemistry ; Rotation</subject><ispartof>Angewandte Chemie International Edition, 2018-08, Vol.57 (34), p.11064-11068</ispartof><rights>2018 Wiley‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><rights>2018 Wiley-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4766-725a94b2bf10c5542f4f58984aa39c6cbc8ee12f91af7482ea78b0ab9620592b3</citedby><cites>FETCH-LOGICAL-c4766-725a94b2bf10c5542f4f58984aa39c6cbc8ee12f91af7482ea78b0ab9620592b3</cites><orcidid>0000-0002-5055-9924</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201804716$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201804716$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29932486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uhl, Edgar</creatorcontrib><creatorcontrib>Thumser, Stefan</creatorcontrib><creatorcontrib>Mayer, Peter</creatorcontrib><creatorcontrib>Dube, Henry</creatorcontrib><title>Transmission of Unidirectional Molecular Motor Rotation to a Remote Biaryl Axis</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Molecular motors undergo repetitive directional motions upon external energy input. A profound challenge is the defined transfer of directional motor motions to remote entities at the molecular scale. Herein, we present a molecular setup that allows for the transfer of the directional rotation of a light‐powered motor unit onto a remote biaryl axis via an ethylene glycol chain link. Based on a combination of X‐ray crystallographic analysis, ECD, and NMR experiments as well as a comprehensive theoretical assessment, we provide evidence for the coupled stepwise directional motions of both molecular units. With the presented setup, facile integration of molecular motor units into larger functional frameworks and complex molecular machines can be explored consciously in the future. Set into motion: The directional rotation of a hemithioindigo‐based molecular motor is effectively transmitted to a remote asymmetric biaryl axis via an ethylene glycol chain. With the presented setup, directional motions can now be relayed to other functional entities against the equilibrating Brownian motion on the molecular scale with high precision.</description><subject>Crystallography</subject><subject>Ethylene glycol</subject><subject>hemithioindigo</subject><subject>isomerization</subject><subject>Molecular machines</subject><subject>Molecular motors</subject><subject>Motor units</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>photochemistry</subject><subject>physical chemistry</subject><subject>Rotation</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLAzEURoMoVqtblxJw42ZqnpNkWUt9gFoo7XrIpBmITCc1mUH7783QWsGNq9xwz_3gOwBcYTTCCJE73Tg7IghLxATOj8AZ5gRnVAh6nGZGaSYkxwNwHuN74qVE-SkYEKUoYTI_A7NF0E1cuxidb6Cv4LJxKxesadNf1_DV19Z0tQ5pan2Ac9_qfgVbDzWc27VvLbx3OmxrOP5y8QKcVLqO9nL_DsHyYbqYPGUvs8fnyfglM0zkeSYI14qVpKwwMpwzUrGKSyWZ1lSZ3JRGWotJpbCuBJPEaiFLpEuVE8QVKekQ3O5yN8F_dDa2RepgbF3rxvouFgmTHNFcyYTe_EHffRdSuZ6SglOOko4hGO0oE3yMwVbFJrh16lVgVPSqi151cVCdDq73sV25tqsD_uM2AWoHfLrabv-JK8Zvz9Pf8G8FVYnX</recordid><startdate>20180820</startdate><enddate>20180820</enddate><creator>Uhl, Edgar</creator><creator>Thumser, Stefan</creator><creator>Mayer, Peter</creator><creator>Dube, Henry</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5055-9924</orcidid></search><sort><creationdate>20180820</creationdate><title>Transmission of Unidirectional Molecular Motor Rotation to a Remote Biaryl Axis</title><author>Uhl, Edgar ; Thumser, Stefan ; Mayer, Peter ; Dube, Henry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4766-725a94b2bf10c5542f4f58984aa39c6cbc8ee12f91af7482ea78b0ab9620592b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Crystallography</topic><topic>Ethylene glycol</topic><topic>hemithioindigo</topic><topic>isomerization</topic><topic>Molecular machines</topic><topic>Molecular motors</topic><topic>Motor units</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>photochemistry</topic><topic>physical chemistry</topic><topic>Rotation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uhl, Edgar</creatorcontrib><creatorcontrib>Thumser, Stefan</creatorcontrib><creatorcontrib>Mayer, Peter</creatorcontrib><creatorcontrib>Dube, Henry</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uhl, Edgar</au><au>Thumser, Stefan</au><au>Mayer, Peter</au><au>Dube, Henry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission of Unidirectional Molecular Motor Rotation to a Remote Biaryl Axis</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2018-08-20</date><risdate>2018</risdate><volume>57</volume><issue>34</issue><spage>11064</spage><epage>11068</epage><pages>11064-11068</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Molecular motors undergo repetitive directional motions upon external energy input. A profound challenge is the defined transfer of directional motor motions to remote entities at the molecular scale. Herein, we present a molecular setup that allows for the transfer of the directional rotation of a light‐powered motor unit onto a remote biaryl axis via an ethylene glycol chain link. Based on a combination of X‐ray crystallographic analysis, ECD, and NMR experiments as well as a comprehensive theoretical assessment, we provide evidence for the coupled stepwise directional motions of both molecular units. With the presented setup, facile integration of molecular motor units into larger functional frameworks and complex molecular machines can be explored consciously in the future. Set into motion: The directional rotation of a hemithioindigo‐based molecular motor is effectively transmitted to a remote asymmetric biaryl axis via an ethylene glycol chain. With the presented setup, directional motions can now be relayed to other functional entities against the equilibrating Brownian motion on the molecular scale with high precision.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29932486</pmid><doi>10.1002/anie.201804716</doi><tpages>5</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0002-5055-9924</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1433-7851
ispartof Angewandte Chemie International Edition, 2018-08, Vol.57 (34), p.11064-11068
issn 1433-7851
1521-3773
language eng
recordid cdi_proquest_miscellaneous_2058503698
source Wiley Online Library All Journals
subjects Crystallography
Ethylene glycol
hemithioindigo
isomerization
Molecular machines
Molecular motors
Motor units
NMR
Nuclear magnetic resonance
photochemistry
physical chemistry
Rotation
title Transmission of Unidirectional Molecular Motor Rotation to a Remote Biaryl Axis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T13%3A33%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transmission%20of%20Unidirectional%20Molecular%20Motor%20Rotation%20to%20a%20Remote%20Biaryl%20Axis&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.au=Uhl,%20Edgar&rft.date=2018-08-20&rft.volume=57&rft.issue=34&rft.spage=11064&rft.epage=11068&rft.pages=11064-11068&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.201804716&rft_dat=%3Cproquest_cross%3E2058503698%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2087535099&rft_id=info:pmid/29932486&rfr_iscdi=true