Potential benefits and harms of NADPH oxidase type 4 in the kidneys and cardiovascular system

Abstract The main function of NADPH oxidases is to catalyse the formation of reactive oxygen species (ROS). NADPH oxidase 4 (NOX4) is expressed at high levels in kidney tubular cells, and at lower levels in endothelial cells, cardiomyocytes and other cell types under physiological conditions. NOX4 i...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2019-04, Vol.34 (4), p.567-576
Hauptverfasser:	Rajaram, Renuga D, Dissard, Romain, Jaquet, Vincent, de Seigneux, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Cardiovascular Diseases - drug therapy Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Enzyme Inhibitors - therapeutic use Humans NADPH Oxidase 4 - antagonists & inhibitors NADPH Oxidase 4 - metabolism Prognosis
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