Single-Molecule Microscopy Reveals Dynamic FLNA Interactions Governing SSTR2 Clustering and Internalization

Abstract The cytoskeletal protein filamin A (FLNA) has been suggested to play an important role in the responsiveness of GH-secreting pituitary tumors to somatostatin receptor subtype 2 (SSTR2) agonists by regulating SSTR2 expression and signaling. However, the underlying mechanisms are unknown. In...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2018-08, Vol.159 (8), p.2953-2965
Hauptverfasser:	Treppiedi, Donatella, Jobin, Marie-Lise, Peverelli, Erika, Giardino, Elena, Sungkaworn, Titiwat, Zabel, Ulrike, Arosio, Maura, Spada, Anna, Mantovani, Giovanna, Calebiro, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Agonists Brain tumors Clathrin Clustering Coated pits Coupling (molecular) Cytoskeleton Endocrinology Fibers Growth hormones Internalization Localization Microscopy Pituitary Signaling Somatostatin Somatostatin receptors Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!