High Level of α-Synuclein mRNA in Peripheral Lymphocytes of Patients with Alcohol Dependence Syndrome
The content of mRNA for α-synuclein (a key protein of the dopaminergic system) was elevated in the peripheral lymphocytes of patients with alcohol dependence syndrome. Increased level of α-synuclein mRNA was not associated with changes in the expression of NR4A2 gene encoding Nurrl, one of the main...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2008-11, Vol.146 (5), p.609-611 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 146 |
| creator | Taraskina, A. E Filimonov, V. A Kozlovskaya, Yu. A Morozova, M. N Gaschin, D. V Schwarzman, A. L |
| description | The content of mRNA for α-synuclein (a key protein of the dopaminergic system) was elevated in the peripheral lymphocytes of patients with alcohol dependence syndrome. Increased level of α-synuclein mRNA was not associated with changes in the expression of NR4A2 gene encoding Nurrl, one of the main transcription factors of dopaminergic neurons. |
| doi_str_mv | 10.1007/s10517-009-0345-1 |
| format | Article |
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| ispartof | Bulletin of experimental biology and medicine, 2008-11, Vol.146 (5), p.609-611 |
| issn | 0007-4888 1573-8221 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult alcohol dependence syndrome Alcoholism - genetics alpha-Synuclein - genetics Analysis of Variance Biomedical and Life Sciences Biomedicine Cell Biology DNA-Binding Proteins - genetics Experimental Genetics gene expression Genetic Predisposition to Disease Humans Internal Medicine Laboratory Medicine Lymphocytes - metabolism Male Middle Aged NR4A2 gene Nuclear Receptor Subfamily 4, Group A, Member 2 Pathology Transcription Factors - genetics α-synuclein α-synuclein gene |
| title | High Level of α-Synuclein mRNA in Peripheral Lymphocytes of Patients with Alcohol Dependence Syndrome |
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