The role of spinal nuclear factor-kappa B in spinal hyperexcitability
In behavioral experiments, inhibition of nuclear factor-κB activation by systemic administration of the IκB kinase inhibitor S1627 has been shown to attenuate inflammatory and neuropathic pain. Here, we specifically investigated with electrophysiological recordings in anesthetized rats whether spina...
Gespeichert in:
| Veröffentlicht in: | Neuroreport 2006-10, Vol.17 (15), p.1615-1618 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1618 |
|---|---|
| container_issue | 15 |
| container_start_page | 1615 |
| container_title | Neuroreport |
| container_volume | 17 |
| creator | Ebersberger, Andrea Buchmann, Melanie Ritzeler, Olaf Michaelis, Martin Schaible, Hans-Georg |
| description | In behavioral experiments, inhibition of nuclear factor-κB activation by systemic administration of the IκB kinase inhibitor S1627 has been shown to attenuate inflammatory and neuropathic pain. Here, we specifically investigated with electrophysiological recordings in anesthetized rats whether spinal application of S1627 influences hyperexcitability of dorsal horn neurons during an acute knee joint inflammation. Spinal application of S1627 before and early during development of inflammation totally prevented spinal hyperexcitability suggesting an important role of spinal nuclear factor-κB in this process. During established inflammation, however, S1627 did not reduce the responses of neurons to mechanical stimulation of the inflamed knee within 2.5 h after spinal administration, thus suggesting that spinal hyperexcitability is not maintained by continuous nuclear factor-κB activation. |
| doi_str_mv | 10.1097/01.wnr.0000236867.76347.60 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20581611</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20581611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4891-c0c82162e0b124f2c0fd46014156e4c8aa9bd9ddf0f2c790ad4fe4981c1f1fde3</originalsourceid><addsrcrecordid>eNpFkEtv1DAQgC0EokvhL6AICW5JZxzHD260KlCpEpdW6s3yOmNtqDcJdqJl_z3Z7qKdy0gz3zz0MfYJoUIw6gqw2vWpgiV4LbVUlZK1UJWEV2yFQtVl0-in12wFpjGlMLK5YO9y_r3wBlC_ZReoAJArs2K3Dxsq0hCpGEKRx653sehnH8mlIjg_Dal8duPoiuui6_8Dm_1Iif76bnLrLnbT_j17E1zM9OGUL9nj99uHm5_l_a8fdzff7ksvtMHSg9ccJSdYIxeBewitkIACG0nCa-fMujVtG2DpKQOuFYGE0egxYGipvmRfjnvHNPyZKU9222VPMbqehjlbDo1GibiAX4-gT0POiYIdU7d1aW8R7EGiBbSLRHuWaF8kWgnL8MfTlXm9pfY8erK2AJ9PgMvexZBc77t85jTqpuaHL8SR2w1xopSf47yjZDfk4rR5OY2qkSUHkLh8AeWhgvU_QUmLOg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20581611</pqid></control><display><type>article</type><title>The role of spinal nuclear factor-kappa B in spinal hyperexcitability</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Ebersberger, Andrea ; Buchmann, Melanie ; Ritzeler, Olaf ; Michaelis, Martin ; Schaible, Hans-Georg</creator><creatorcontrib>Ebersberger, Andrea ; Buchmann, Melanie ; Ritzeler, Olaf ; Michaelis, Martin ; Schaible, Hans-Georg</creatorcontrib><description>In behavioral experiments, inhibition of nuclear factor-κB activation by systemic administration of the IκB kinase inhibitor S1627 has been shown to attenuate inflammatory and neuropathic pain. Here, we specifically investigated with electrophysiological recordings in anesthetized rats whether spinal application of S1627 influences hyperexcitability of dorsal horn neurons during an acute knee joint inflammation. Spinal application of S1627 before and early during development of inflammation totally prevented spinal hyperexcitability suggesting an important role of spinal nuclear factor-κB in this process. During established inflammation, however, S1627 did not reduce the responses of neurons to mechanical stimulation of the inflamed knee within 2.5 h after spinal administration, thus suggesting that spinal hyperexcitability is not maintained by continuous nuclear factor-κB activation.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/01.wnr.0000236867.76347.60</identifier><identifier>PMID: 17001279</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Arthritis, Experimental - chemically induced ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - pathology ; Arthritis, Experimental - physiopathology ; Biological and medical sciences ; Cell physiology ; Enzyme Inhibitors - pharmacology ; Enzyme Inhibitors - therapeutic use ; Fundamental and applied biological sciences. Psychology ; Male ; Molecular and cellular biology ; NF-kappa B - antagonists & inhibitors ; NF-kappa B - physiology ; Posterior Horn Cells - drug effects ; Posterior Horn Cells - physiology ; Rats ; Rats, Wistar ; Responses to growth factors, tumor promotors, other factors ; Spinal Cord - cytology ; Time Factors</subject><ispartof>Neuroreport, 2006-10, Vol.17 (15), p.1615-1618</ispartof><rights>2006 Lippincott Williams & Wilkins, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4891-c0c82162e0b124f2c0fd46014156e4c8aa9bd9ddf0f2c790ad4fe4981c1f1fde3</citedby><cites>FETCH-LOGICAL-c4891-c0c82162e0b124f2c0fd46014156e4c8aa9bd9ddf0f2c790ad4fe4981c1f1fde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18185321$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17001279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ebersberger, Andrea</creatorcontrib><creatorcontrib>Buchmann, Melanie</creatorcontrib><creatorcontrib>Ritzeler, Olaf</creatorcontrib><creatorcontrib>Michaelis, Martin</creatorcontrib><creatorcontrib>Schaible, Hans-Georg</creatorcontrib><title>The role of spinal nuclear factor-kappa B in spinal hyperexcitability</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>In behavioral experiments, inhibition of nuclear factor-κB activation by systemic administration of the IκB kinase inhibitor S1627 has been shown to attenuate inflammatory and neuropathic pain. Here, we specifically investigated with electrophysiological recordings in anesthetized rats whether spinal application of S1627 influences hyperexcitability of dorsal horn neurons during an acute knee joint inflammation. Spinal application of S1627 before and early during development of inflammation totally prevented spinal hyperexcitability suggesting an important role of spinal nuclear factor-κB in this process. During established inflammation, however, S1627 did not reduce the responses of neurons to mechanical stimulation of the inflamed knee within 2.5 h after spinal administration, thus suggesting that spinal hyperexcitability is not maintained by continuous nuclear factor-κB activation.</description><subject>Animals</subject><subject>Arthritis, Experimental - chemically induced</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - pathology</subject><subject>Arthritis, Experimental - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>NF-kappa B - antagonists & inhibitors</subject><subject>NF-kappa B - physiology</subject><subject>Posterior Horn Cells - drug effects</subject><subject>Posterior Horn Cells - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Spinal Cord - cytology</subject><subject>Time Factors</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtv1DAQgC0EokvhL6AICW5JZxzHD260KlCpEpdW6s3yOmNtqDcJdqJl_z3Z7qKdy0gz3zz0MfYJoUIw6gqw2vWpgiV4LbVUlZK1UJWEV2yFQtVl0-in12wFpjGlMLK5YO9y_r3wBlC_ZReoAJArs2K3Dxsq0hCpGEKRx653sehnH8mlIjg_Dal8duPoiuui6_8Dm_1Iif76bnLrLnbT_j17E1zM9OGUL9nj99uHm5_l_a8fdzff7ksvtMHSg9ccJSdYIxeBewitkIACG0nCa-fMujVtG2DpKQOuFYGE0egxYGipvmRfjnvHNPyZKU9222VPMbqehjlbDo1GibiAX4-gT0POiYIdU7d1aW8R7EGiBbSLRHuWaF8kWgnL8MfTlXm9pfY8erK2AJ9PgMvexZBc77t85jTqpuaHL8SR2w1xopSf47yjZDfk4rR5OY2qkSUHkLh8AeWhgvU_QUmLOg</recordid><startdate>20061023</startdate><enddate>20061023</enddate><creator>Ebersberger, Andrea</creator><creator>Buchmann, Melanie</creator><creator>Ritzeler, Olaf</creator><creator>Michaelis, Martin</creator><creator>Schaible, Hans-Georg</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20061023</creationdate><title>The role of spinal nuclear factor-kappa B in spinal hyperexcitability</title><author>Ebersberger, Andrea ; Buchmann, Melanie ; Ritzeler, Olaf ; Michaelis, Martin ; Schaible, Hans-Georg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4891-c0c82162e0b124f2c0fd46014156e4c8aa9bd9ddf0f2c790ad4fe4981c1f1fde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Arthritis, Experimental - chemically induced</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - pathology</topic><topic>Arthritis, Experimental - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>NF-kappa B - antagonists & inhibitors</topic><topic>NF-kappa B - physiology</topic><topic>Posterior Horn Cells - drug effects</topic><topic>Posterior Horn Cells - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Spinal Cord - cytology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ebersberger, Andrea</creatorcontrib><creatorcontrib>Buchmann, Melanie</creatorcontrib><creatorcontrib>Ritzeler, Olaf</creatorcontrib><creatorcontrib>Michaelis, Martin</creatorcontrib><creatorcontrib>Schaible, Hans-Georg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ebersberger, Andrea</au><au>Buchmann, Melanie</au><au>Ritzeler, Olaf</au><au>Michaelis, Martin</au><au>Schaible, Hans-Georg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of spinal nuclear factor-kappa B in spinal hyperexcitability</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2006-10-23</date><risdate>2006</risdate><volume>17</volume><issue>15</issue><spage>1615</spage><epage>1618</epage><pages>1615-1618</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>In behavioral experiments, inhibition of nuclear factor-κB activation by systemic administration of the IκB kinase inhibitor S1627 has been shown to attenuate inflammatory and neuropathic pain. Here, we specifically investigated with electrophysiological recordings in anesthetized rats whether spinal application of S1627 influences hyperexcitability of dorsal horn neurons during an acute knee joint inflammation. Spinal application of S1627 before and early during development of inflammation totally prevented spinal hyperexcitability suggesting an important role of spinal nuclear factor-κB in this process. During established inflammation, however, S1627 did not reduce the responses of neurons to mechanical stimulation of the inflamed knee within 2.5 h after spinal administration, thus suggesting that spinal hyperexcitability is not maintained by continuous nuclear factor-κB activation.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>17001279</pmid><doi>10.1097/01.wnr.0000236867.76347.60</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 2006-10, Vol.17 (15), p.1615-1618 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20581611 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Arthritis, Experimental - pathology Arthritis, Experimental - physiopathology Biological and medical sciences Cell physiology Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Fundamental and applied biological sciences. Psychology Male Molecular and cellular biology NF-kappa B - antagonists & inhibitors NF-kappa B - physiology Posterior Horn Cells - drug effects Posterior Horn Cells - physiology Rats Rats, Wistar Responses to growth factors, tumor promotors, other factors Spinal Cord - cytology Time Factors |
| title | The role of spinal nuclear factor-kappa B in spinal hyperexcitability |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A49%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20spinal%20nuclear%20factor-kappa%20B%20in%20spinal%20hyperexcitability&rft.jtitle=Neuroreport&rft.au=Ebersberger,%20Andrea&rft.date=2006-10-23&rft.volume=17&rft.issue=15&rft.spage=1615&rft.epage=1618&rft.pages=1615-1618&rft.issn=0959-4965&rft.eissn=1473-558X&rft_id=info:doi/10.1097/01.wnr.0000236867.76347.60&rft_dat=%3Cproquest_cross%3E20581611%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20581611&rft_id=info:pmid/17001279&rfr_iscdi=true |