[6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions

Reactive nitrogen species (RNS), such as nitric oxide (NO) and its derivatives, e.g. peroxynitrite (ONOO −), have been proposed as being able to influence signal transduction and cause DNA damage, contributing to carcinogenic processes. In this study, the effect of [6]-gingerol, a pungent phenolic c...

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Veröffentlicht in:	Life sciences (1973) 2003-11, Vol.73 (26), p.3427-3437
Hauptverfasser:	Ippoushi, Katsunari, Azuma, Keiko, Ito, Hidekazu, Horie, Hideki, Higashio, Hisao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catechols Cells, Cultured DNA Damage - drug effects Dose-Response Relationship, Drug Enzyme Induction Fatty Alcohols - pharmacology Fluoresceins - metabolism Ginger Gingerol Lipopolysaccharides - pharmacology Macrophage Activation - drug effects Macrophage Activation - physiology Macrophages Macrophages - drug effects Macrophages - enzymology Mice Nitration Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Oxidation Oxidation-Reduction Peroxynitrite Peroxynitrous Acid - pharmacology Reactive nitrogen species Zingiber officinale Zingiber officinale Roscoe
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