Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor
We have previously developed a polycaprolactone (PCL) vascular graft with incorporated vascular endothelial growth factor (VEGF). Functioning of the PCL/VEGF graft in rat circulatory system over 1, 3 and 6 months after implantation into abdominal aorta was tested. Graft patency and formation of vasc...
Gespeichert in:
| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-06, Vol.165 (2), p.264-268 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 268 |
|---|---|
| container_issue | 2 |
| container_start_page | 264 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 165 |
| creator | Sevostyanova, V. V. Antonova, L. V. Velikanova, E. A. Matveeva, V. G. Krivkina, E. O. Glushkova, T. V. Mironov, A. V. Burago, A. Yu Barbarash, L. S. |
| description | We have previously developed a polycaprolactone (PCL) vascular graft with incorporated vascular endothelial growth factor (VEGF). Functioning of the PCL/VEGF graft in rat circulatory system over 1, 3 and 6 months after implantation into abdominal aorta was tested. Graft patency and formation of vascular wall elements were assessed histologically and by immunofluorescence staining for von Willebrand factor, CD31, CD34, and collagens I and IV and DAPI staining. Local application of VEGF promoted endothelialization and improved patency of the graft. The wall of the PCL/VEGF graft underwent remodeling due to active cellular infiltration and the extracellular matrix deposition. |
| doi_str_mv | 10.1007/s10517-018-4144-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2057870449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A546649144</galeid><sourcerecordid>A546649144</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-328a5b2d40054601e054bd15eb91ebd1eef2f02c05e0a04e2b40b7b17e8205d53</originalsourceid><addsrcrecordid>eNp1kk1v1DAQhi0EokvhB3BBkZAQl5Sx14mT46pqC9JKcACuluNMuq688WI7Qov48UzYlm0RyIfxx_OOZ-yXsZcczjiAepc4VFyVwJtScilL-YgteKWWZSMEf8wWQFApm6Y5Yc9SupmXUPOn7ES0raiFqhfs58XYh7xB74x3P0x2YSzCUHwKfm_NLgZvbA4jFl9NspM3sbiKZsjFNPYYC9IVK3unWQdrvN8Xq93OO-yPkntXkDx8z5vick4bn7Mng_EJX9zGU_bl8uLz-fty_fHqw_lqXVqpIJdL0ZiqE70EqGQNHCl0Pa-waznSBHEQAwgLFYIBiaKT0KmOK2wEVH21PGVvD3mpoW8Tpqy3Lln03owYpqSJUo0CKVtCX_-F3oQpjlTdb0q0vAV1pK6NR-3GIeRo7JxUr6jEWrb0HUSd_YOi0ePWWXrVwdH-A8Gbe4INGp83KfhpfuH0EOQH0MaQUsRB76LbmrjXHPRsDX2whiZr6Nkaeta8uu1s6rbY_1HceYEAcQASHY3XGI-t_z_rL9cxwh8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2057291907</pqid></control><display><type>article</type><title>Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Sevostyanova, V. V. ; Antonova, L. V. ; Velikanova, E. A. ; Matveeva, V. G. ; Krivkina, E. O. ; Glushkova, T. V. ; Mironov, A. V. ; Burago, A. Yu ; Barbarash, L. S.</creator><creatorcontrib>Sevostyanova, V. V. ; Antonova, L. V. ; Velikanova, E. A. ; Matveeva, V. G. ; Krivkina, E. O. ; Glushkova, T. V. ; Mironov, A. V. ; Burago, A. Yu ; Barbarash, L. S.</creatorcontrib><description>We have previously developed a polycaprolactone (PCL) vascular graft with incorporated vascular endothelial growth factor (VEGF). Functioning of the PCL/VEGF graft in rat circulatory system over 1, 3 and 6 months after implantation into abdominal aorta was tested. Graft patency and formation of vascular wall elements were assessed histologically and by immunofluorescence staining for von Willebrand factor, CD31, CD34, and collagens I and IV and DAPI staining. Local application of VEGF promoted endothelialization and improved patency of the graft. The wall of the PCL/VEGF graft underwent remodeling due to active cellular infiltration and the extracellular matrix deposition.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-018-4144-4</identifier><identifier>PMID: 29926276</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Aorta ; Aorta, Abdominal - cytology ; Aorta, Abdominal - drug effects ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Blood Vessel Prosthesis ; CD34 antigen ; Cell Biology ; Cell Proliferation - drug effects ; Circulatory system ; Collagen ; Endothelial Cells - cytology ; Endothelial Cells - drug effects ; Endothelial Cells - physiology ; Endothelium, Vascular - cytology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; Extracellular matrix ; Extracellular Matrix - drug effects ; Extracellular Matrix - metabolism ; Immunofluorescence ; Internal Medicine ; Laboratory Medicine ; Male ; Organ transplantation ; Pathology ; Political corruption ; Polycaprolactone ; Polyesters - chemistry ; Rats ; Rats, Wistar ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factors - pharmacology ; Vascular Grafting ; Vascular Remodeling - drug effects ; Von Willebrand factor</subject><ispartof>Bulletin of experimental biology and medicine, 2018-06, Vol.165 (2), p.264-268</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-328a5b2d40054601e054bd15eb91ebd1eef2f02c05e0a04e2b40b7b17e8205d53</citedby><cites>FETCH-LOGICAL-c470t-328a5b2d40054601e054bd15eb91ebd1eef2f02c05e0a04e2b40b7b17e8205d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-018-4144-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-018-4144-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29926276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sevostyanova, V. V.</creatorcontrib><creatorcontrib>Antonova, L. V.</creatorcontrib><creatorcontrib>Velikanova, E. A.</creatorcontrib><creatorcontrib>Matveeva, V. G.</creatorcontrib><creatorcontrib>Krivkina, E. O.</creatorcontrib><creatorcontrib>Glushkova, T. V.</creatorcontrib><creatorcontrib>Mironov, A. V.</creatorcontrib><creatorcontrib>Burago, A. Yu</creatorcontrib><creatorcontrib>Barbarash, L. S.</creatorcontrib><title>Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We have previously developed a polycaprolactone (PCL) vascular graft with incorporated vascular endothelial growth factor (VEGF). Functioning of the PCL/VEGF graft in rat circulatory system over 1, 3 and 6 months after implantation into abdominal aorta was tested. Graft patency and formation of vascular wall elements were assessed histologically and by immunofluorescence staining for von Willebrand factor, CD31, CD34, and collagens I and IV and DAPI staining. Local application of VEGF promoted endothelialization and improved patency of the graft. The wall of the PCL/VEGF graft underwent remodeling due to active cellular infiltration and the extracellular matrix deposition.</description><subject>Animals</subject><subject>Aorta</subject><subject>Aorta, Abdominal - cytology</subject><subject>Aorta, Abdominal - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Blood Vessel Prosthesis</subject><subject>CD34 antigen</subject><subject>Cell Biology</subject><subject>Cell Proliferation - drug effects</subject><subject>Circulatory system</subject><subject>Collagen</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - physiology</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - drug effects</subject><subject>Extracellular Matrix - metabolism</subject><subject>Immunofluorescence</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Organ transplantation</subject><subject>Pathology</subject><subject>Political corruption</subject><subject>Polycaprolactone</subject><subject>Polyesters - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factors - pharmacology</subject><subject>Vascular Grafting</subject><subject>Vascular Remodeling - drug effects</subject><subject>Von Willebrand factor</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1v1DAQhi0EokvhB3BBkZAQl5Sx14mT46pqC9JKcACuluNMuq688WI7Qov48UzYlm0RyIfxx_OOZ-yXsZcczjiAepc4VFyVwJtScilL-YgteKWWZSMEf8wWQFApm6Y5Yc9SupmXUPOn7ES0raiFqhfs58XYh7xB74x3P0x2YSzCUHwKfm_NLgZvbA4jFl9NspM3sbiKZsjFNPYYC9IVK3unWQdrvN8Xq93OO-yPkntXkDx8z5vick4bn7Mng_EJX9zGU_bl8uLz-fty_fHqw_lqXVqpIJdL0ZiqE70EqGQNHCl0Pa-waznSBHEQAwgLFYIBiaKT0KmOK2wEVH21PGVvD3mpoW8Tpqy3Lln03owYpqSJUo0CKVtCX_-F3oQpjlTdb0q0vAV1pK6NR-3GIeRo7JxUr6jEWrb0HUSd_YOi0ePWWXrVwdH-A8Gbe4INGp83KfhpfuH0EOQH0MaQUsRB76LbmrjXHPRsDX2whiZr6Nkaeta8uu1s6rbY_1HceYEAcQASHY3XGI-t_z_rL9cxwh8</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Sevostyanova, V. V.</creator><creator>Antonova, L. V.</creator><creator>Velikanova, E. A.</creator><creator>Matveeva, V. G.</creator><creator>Krivkina, E. O.</creator><creator>Glushkova, T. V.</creator><creator>Mironov, A. V.</creator><creator>Burago, A. Yu</creator><creator>Barbarash, L. S.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180601</creationdate><title>Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor</title><author>Sevostyanova, V. V. ; Antonova, L. V. ; Velikanova, E. A. ; Matveeva, V. G. ; Krivkina, E. O. ; Glushkova, T. V. ; Mironov, A. V. ; Burago, A. Yu ; Barbarash, L. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-328a5b2d40054601e054bd15eb91ebd1eef2f02c05e0a04e2b40b7b17e8205d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Aorta, Abdominal - cytology</topic><topic>Aorta, Abdominal - drug effects</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Blood Vessel Prosthesis</topic><topic>CD34 antigen</topic><topic>Cell Biology</topic><topic>Cell Proliferation - drug effects</topic><topic>Circulatory system</topic><topic>Collagen</topic><topic>Endothelial Cells - cytology</topic><topic>Endothelial Cells - drug effects</topic><topic>Endothelial Cells - physiology</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiology</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - drug effects</topic><topic>Extracellular Matrix - metabolism</topic><topic>Immunofluorescence</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Organ transplantation</topic><topic>Pathology</topic><topic>Political corruption</topic><topic>Polycaprolactone</topic><topic>Polyesters - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factors - pharmacology</topic><topic>Vascular Grafting</topic><topic>Vascular Remodeling - drug effects</topic><topic>Von Willebrand factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sevostyanova, V. V.</creatorcontrib><creatorcontrib>Antonova, L. V.</creatorcontrib><creatorcontrib>Velikanova, E. A.</creatorcontrib><creatorcontrib>Matveeva, V. G.</creatorcontrib><creatorcontrib>Krivkina, E. O.</creatorcontrib><creatorcontrib>Glushkova, T. V.</creatorcontrib><creatorcontrib>Mironov, A. V.</creatorcontrib><creatorcontrib>Burago, A. Yu</creatorcontrib><creatorcontrib>Barbarash, L. S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sevostyanova, V. V.</au><au>Antonova, L. V.</au><au>Velikanova, E. A.</au><au>Matveeva, V. G.</au><au>Krivkina, E. O.</au><au>Glushkova, T. V.</au><au>Mironov, A. V.</au><au>Burago, A. Yu</au><au>Barbarash, L. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>165</volume><issue>2</issue><spage>264</spage><epage>268</epage><pages>264-268</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We have previously developed a polycaprolactone (PCL) vascular graft with incorporated vascular endothelial growth factor (VEGF). Functioning of the PCL/VEGF graft in rat circulatory system over 1, 3 and 6 months after implantation into abdominal aorta was tested. Graft patency and formation of vascular wall elements were assessed histologically and by immunofluorescence staining for von Willebrand factor, CD31, CD34, and collagens I and IV and DAPI staining. Local application of VEGF promoted endothelialization and improved patency of the graft. The wall of the PCL/VEGF graft underwent remodeling due to active cellular infiltration and the extracellular matrix deposition.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29926276</pmid><doi>10.1007/s10517-018-4144-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2018-06, Vol.165 (2), p.264-268 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2057870449 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Aorta Aorta, Abdominal - cytology Aorta, Abdominal - drug effects Biomedical and Life Sciences Biomedicine Biotechnology Blood Vessel Prosthesis CD34 antigen Cell Biology Cell Proliferation - drug effects Circulatory system Collagen Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - physiology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Immunofluorescence Internal Medicine Laboratory Medicine Male Organ transplantation Pathology Political corruption Polycaprolactone Polyesters - chemistry Rats Rats, Wistar Vascular endothelial growth factor Vascular Endothelial Growth Factors - pharmacology Vascular Grafting Vascular Remodeling - drug effects Von Willebrand factor |
| title | Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T19%3A20%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endothelialization%20of%20Polycaprolactone%20Vascular%20Graft%20under%20the%20Action%20of%20Locally%20Applied%20Vascular%20Endothelial%20Growth%20Factor&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Sevostyanova,%20V.%20V.&rft.date=2018-06-01&rft.volume=165&rft.issue=2&rft.spage=264&rft.epage=268&rft.pages=264-268&rft.issn=0007-4888&rft.eissn=1573-8221&rft_id=info:doi/10.1007/s10517-018-4144-4&rft_dat=%3Cgale_proqu%3EA546649144%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2057291907&rft_id=info:pmid/29926276&rft_galeid=A546649144&rfr_iscdi=true |