Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate
Prolactin (PRL), growth hormone (GH), and insulin-like growth factor-1 (IGF-1) are in hormone-response pathways involved in energy metabolism during thermoregulation processes in cattle. Objective herein was to study the association between single nucleotide polymorphisms (SNP) within genes of the P...
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| creator | Leyva-Corona, Jose C. Reyna-Granados, Javier R. Zamorano-Algandar, Ricardo Sanchez-Castro, Miguel A. Thomas, Milton G. Enns, R. Mark Speidel, Scott E. Medrano, Juan F. Rincon, Gonzalo Luna-Nevarez, Pablo |
| description | Prolactin (PRL), growth hormone (GH), and insulin-like growth factor-1 (IGF-1) are in hormone-response pathways involved in energy metabolism during thermoregulation processes in cattle. Objective herein was to study the association between single nucleotide polymorphisms (SNP) within genes of the PRL and GH/IGF-1 pathways with fertility traits such as services per conception (SPC) and days open (DO) in Holstein cattle lactating under a hot-humid climate. Ambient temperature and relative humidity were used to calculate the temperature-humidity index (THI) which revealed that the cows were exposed to heat stress conditions from June to November of 2012 in southern Sonora, Mexico. Individual blood samples from all cows were collected, spotted on FTA cards, and used to genotype a 179 tag SNP panel within 44 genes from the PRL and GH/IGF-1 pathways. The associative analyses among SNP genotypes and fertility traits were performed using mixed-effect models. Allele substitution effects were calculated using a regression model that included the genotype term as covariate. Single-SNP association analyses indicated that eight SNP within the genes
IGF-1
,
IGF-1R
,
IGFBP5
,
PAPPA1
,
PMCH
,
PRLR
,
SOCS5
, and
SSTR2
were associated with SPC (
P
|
| doi_str_mv | 10.1007/s11250-018-1645-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2057869291</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2057869291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-acafa489b53d17d6fdb90eb69e23e3610cdba94c6ccf317702d5506e0bdffc443</originalsourceid><addsrcrecordid>eNp1kc9uFSEYxYnR2Gv1AdwYEjdusMAwMCxNo7ZJE13oesIA06Eyw5WPyc19sT6fXKfVxMQVf77fOSdwEHrN6HtGqboAxnhLCWUdYVK0hD5BO9aqhijRdE_RjlKhiVBCnaEXAHeUVlUnn6MzrjWXjeQ7dP81xeOc8n4KMAM-hDKFBZfJ431O0dhST2Zx-DanQ5nwlPKcFn8RFlhjWEgMP_zjbKx0yoThcV2qLi0m4r0p08EcARuAZIMp3v3OwKPPJcRQjrhkEwrgmnOVIhRfNzYdANdrqPQpv8YWMq1zcNjGMFeXl-jZaCL4Vw_rOfr-6eO3yyty8-Xz9eWHG2IbxQsx1oxGdHpoG8eUk6MbNPWD1J43vpGMWjcYLay0dmyYUpS7tqXS08GNoxWiOUfvNt_6Gz9XD6WfA1gfo1l8WqHntFWd1Fyzir79B71La66fsFFcCsF0pdhG2ZwAsh_7fa4vysee0f5Uar-V2tdS-1OpPa2aNw_O6zB790fx2GIF-AZAHS23Pv-N_r_rL4c2sh0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2057264419</pqid></control><display><type>article</type><title>Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate</title><source>SpringerLink Journals - AutoHoldings</source><creator>Leyva-Corona, Jose C. ; Reyna-Granados, Javier R. ; Zamorano-Algandar, Ricardo ; Sanchez-Castro, Miguel A. ; Thomas, Milton G. ; Enns, R. Mark ; Speidel, Scott E. ; Medrano, Juan F. ; Rincon, Gonzalo ; Luna-Nevarez, Pablo</creator><creatorcontrib>Leyva-Corona, Jose C. ; Reyna-Granados, Javier R. ; Zamorano-Algandar, Ricardo ; Sanchez-Castro, Miguel A. ; Thomas, Milton G. ; Enns, R. Mark ; Speidel, Scott E. ; Medrano, Juan F. ; Rincon, Gonzalo ; Luna-Nevarez, Pablo</creatorcontrib><description>Prolactin (PRL), growth hormone (GH), and insulin-like growth factor-1 (IGF-1) are in hormone-response pathways involved in energy metabolism during thermoregulation processes in cattle. Objective herein was to study the association between single nucleotide polymorphisms (SNP) within genes of the PRL and GH/IGF-1 pathways with fertility traits such as services per conception (SPC) and days open (DO) in Holstein cattle lactating under a hot-humid climate. Ambient temperature and relative humidity were used to calculate the temperature-humidity index (THI) which revealed that the cows were exposed to heat stress conditions from June to November of 2012 in southern Sonora, Mexico. Individual blood samples from all cows were collected, spotted on FTA cards, and used to genotype a 179 tag SNP panel within 44 genes from the PRL and GH/IGF-1 pathways. The associative analyses among SNP genotypes and fertility traits were performed using mixed-effect models. Allele substitution effects were calculated using a regression model that included the genotype term as covariate. Single-SNP association analyses indicated that eight SNP within the genes
IGF-1
,
IGF-1R
,
IGFBP5
,
PAPPA1
,
PMCH
,
PRLR
,
SOCS5
, and
SSTR2
were associated with SPC (
P
< 0.05), whereas four SNP in the genes
GHR
,
PAPPA2
,
PRLR
, and
SOCS4
were associated with DO (
P
< 0.05). In conclusion, SNP within genes of the PRL and GH/IGF-1 pathways resulted as predictors of reproductive phenotypes in heat-stressed Holstein cows, and these SNP are proposed as candidates for a marker-assisted selection program intended to improve fertility of dairy cattle raised in warm climates.</description><identifier>ISSN: 0049-4747</identifier><identifier>EISSN: 1573-7438</identifier><identifier>DOI: 10.1007/s11250-018-1645-0</identifier><identifier>PMID: 29926362</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Ambient temperature ; Biomedical and Life Sciences ; Bovidae ; Cattle ; Dairy cattle ; Energy metabolism ; Fertility ; Genes ; Genotypes ; Growth hormones ; Heat stress ; Heat tolerance ; Humid climates ; Humidity ; Insulin ; Insulin-like growth factor I ; Insulin-like growth factor-binding protein 5 ; Insulin-like growth factors ; Life Sciences ; Marker-assisted selection ; Metabolism ; Phenotypes ; Prolactin ; Regression analysis ; Regression models ; Regular Articles ; Relative humidity ; Single-nucleotide polymorphism ; Thermoregulation ; Veterinary Medicine/Veterinary Science ; Zoology</subject><ispartof>Tropical animal health and production, 2018-12, Vol.50 (8), p.1913-1920</ispartof><rights>Springer Nature B.V. 2018</rights><rights>Tropical Animal Health and Production is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-acafa489b53d17d6fdb90eb69e23e3610cdba94c6ccf317702d5506e0bdffc443</citedby><cites>FETCH-LOGICAL-c372t-acafa489b53d17d6fdb90eb69e23e3610cdba94c6ccf317702d5506e0bdffc443</cites><orcidid>0000-0003-4814-9851</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11250-018-1645-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11250-018-1645-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29926362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leyva-Corona, Jose C.</creatorcontrib><creatorcontrib>Reyna-Granados, Javier R.</creatorcontrib><creatorcontrib>Zamorano-Algandar, Ricardo</creatorcontrib><creatorcontrib>Sanchez-Castro, Miguel A.</creatorcontrib><creatorcontrib>Thomas, Milton G.</creatorcontrib><creatorcontrib>Enns, R. Mark</creatorcontrib><creatorcontrib>Speidel, Scott E.</creatorcontrib><creatorcontrib>Medrano, Juan F.</creatorcontrib><creatorcontrib>Rincon, Gonzalo</creatorcontrib><creatorcontrib>Luna-Nevarez, Pablo</creatorcontrib><title>Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate</title><title>Tropical animal health and production</title><addtitle>Trop Anim Health Prod</addtitle><addtitle>Trop Anim Health Prod</addtitle><description>Prolactin (PRL), growth hormone (GH), and insulin-like growth factor-1 (IGF-1) are in hormone-response pathways involved in energy metabolism during thermoregulation processes in cattle. Objective herein was to study the association between single nucleotide polymorphisms (SNP) within genes of the PRL and GH/IGF-1 pathways with fertility traits such as services per conception (SPC) and days open (DO) in Holstein cattle lactating under a hot-humid climate. Ambient temperature and relative humidity were used to calculate the temperature-humidity index (THI) which revealed that the cows were exposed to heat stress conditions from June to November of 2012 in southern Sonora, Mexico. Individual blood samples from all cows were collected, spotted on FTA cards, and used to genotype a 179 tag SNP panel within 44 genes from the PRL and GH/IGF-1 pathways. The associative analyses among SNP genotypes and fertility traits were performed using mixed-effect models. Allele substitution effects were calculated using a regression model that included the genotype term as covariate. Single-SNP association analyses indicated that eight SNP within the genes
IGF-1
,
IGF-1R
,
IGFBP5
,
PAPPA1
,
PMCH
,
PRLR
,
SOCS5
, and
SSTR2
were associated with SPC (
P
< 0.05), whereas four SNP in the genes
GHR
,
PAPPA2
,
PRLR
, and
SOCS4
were associated with DO (
P
< 0.05). In conclusion, SNP within genes of the PRL and GH/IGF-1 pathways resulted as predictors of reproductive phenotypes in heat-stressed Holstein cows, and these SNP are proposed as candidates for a marker-assisted selection program intended to improve fertility of dairy cattle raised in warm climates.</description><subject>Ambient temperature</subject><subject>Biomedical and Life Sciences</subject><subject>Bovidae</subject><subject>Cattle</subject><subject>Dairy cattle</subject><subject>Energy metabolism</subject><subject>Fertility</subject><subject>Genes</subject><subject>Genotypes</subject><subject>Growth hormones</subject><subject>Heat stress</subject><subject>Heat tolerance</subject><subject>Humid climates</subject><subject>Humidity</subject><subject>Insulin</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-like growth factor-binding protein 5</subject><subject>Insulin-like growth factors</subject><subject>Life Sciences</subject><subject>Marker-assisted selection</subject><subject>Metabolism</subject><subject>Phenotypes</subject><subject>Prolactin</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Regular Articles</subject><subject>Relative humidity</subject><subject>Single-nucleotide polymorphism</subject><subject>Thermoregulation</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>Zoology</subject><issn>0049-4747</issn><issn>1573-7438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc9uFSEYxYnR2Gv1AdwYEjdusMAwMCxNo7ZJE13oesIA06Eyw5WPyc19sT6fXKfVxMQVf77fOSdwEHrN6HtGqboAxnhLCWUdYVK0hD5BO9aqhijRdE_RjlKhiVBCnaEXAHeUVlUnn6MzrjWXjeQ7dP81xeOc8n4KMAM-hDKFBZfJ431O0dhST2Zx-DanQ5nwlPKcFn8RFlhjWEgMP_zjbKx0yoThcV2qLi0m4r0p08EcARuAZIMp3v3OwKPPJcRQjrhkEwrgmnOVIhRfNzYdANdrqPQpv8YWMq1zcNjGMFeXl-jZaCL4Vw_rOfr-6eO3yyty8-Xz9eWHG2IbxQsx1oxGdHpoG8eUk6MbNPWD1J43vpGMWjcYLay0dmyYUpS7tqXS08GNoxWiOUfvNt_6Gz9XD6WfA1gfo1l8WqHntFWd1Fyzir79B71La66fsFFcCsF0pdhG2ZwAsh_7fa4vysee0f5Uar-V2tdS-1OpPa2aNw_O6zB790fx2GIF-AZAHS23Pv-N_r_rL4c2sh0</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Leyva-Corona, Jose C.</creator><creator>Reyna-Granados, Javier R.</creator><creator>Zamorano-Algandar, Ricardo</creator><creator>Sanchez-Castro, Miguel A.</creator><creator>Thomas, Milton G.</creator><creator>Enns, R. Mark</creator><creator>Speidel, Scott E.</creator><creator>Medrano, Juan F.</creator><creator>Rincon, Gonzalo</creator><creator>Luna-Nevarez, Pablo</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4814-9851</orcidid></search><sort><creationdate>20181201</creationdate><title>Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate</title><author>Leyva-Corona, Jose C. ; Reyna-Granados, Javier R. ; Zamorano-Algandar, Ricardo ; Sanchez-Castro, Miguel A. ; Thomas, Milton G. ; Enns, R. Mark ; Speidel, Scott E. ; Medrano, Juan F. ; Rincon, Gonzalo ; Luna-Nevarez, Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-acafa489b53d17d6fdb90eb69e23e3610cdba94c6ccf317702d5506e0bdffc443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Ambient temperature</topic><topic>Biomedical and Life Sciences</topic><topic>Bovidae</topic><topic>Cattle</topic><topic>Dairy cattle</topic><topic>Energy metabolism</topic><topic>Fertility</topic><topic>Genes</topic><topic>Genotypes</topic><topic>Growth hormones</topic><topic>Heat stress</topic><topic>Heat tolerance</topic><topic>Humid climates</topic><topic>Humidity</topic><topic>Insulin</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-like growth factor-binding protein 5</topic><topic>Insulin-like growth factors</topic><topic>Life Sciences</topic><topic>Marker-assisted selection</topic><topic>Metabolism</topic><topic>Phenotypes</topic><topic>Prolactin</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Regular Articles</topic><topic>Relative humidity</topic><topic>Single-nucleotide polymorphism</topic><topic>Thermoregulation</topic><topic>Veterinary Medicine/Veterinary Science</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leyva-Corona, Jose C.</creatorcontrib><creatorcontrib>Reyna-Granados, Javier R.</creatorcontrib><creatorcontrib>Zamorano-Algandar, Ricardo</creatorcontrib><creatorcontrib>Sanchez-Castro, Miguel A.</creatorcontrib><creatorcontrib>Thomas, Milton G.</creatorcontrib><creatorcontrib>Enns, R. Mark</creatorcontrib><creatorcontrib>Speidel, Scott E.</creatorcontrib><creatorcontrib>Medrano, Juan F.</creatorcontrib><creatorcontrib>Rincon, Gonzalo</creatorcontrib><creatorcontrib>Luna-Nevarez, Pablo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Tropical animal health and production</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leyva-Corona, Jose C.</au><au>Reyna-Granados, Javier R.</au><au>Zamorano-Algandar, Ricardo</au><au>Sanchez-Castro, Miguel A.</au><au>Thomas, Milton G.</au><au>Enns, R. Mark</au><au>Speidel, Scott E.</au><au>Medrano, Juan F.</au><au>Rincon, Gonzalo</au><au>Luna-Nevarez, Pablo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate</atitle><jtitle>Tropical animal health and production</jtitle><stitle>Trop Anim Health Prod</stitle><addtitle>Trop Anim Health Prod</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>50</volume><issue>8</issue><spage>1913</spage><epage>1920</epage><pages>1913-1920</pages><issn>0049-4747</issn><eissn>1573-7438</eissn><abstract>Prolactin (PRL), growth hormone (GH), and insulin-like growth factor-1 (IGF-1) are in hormone-response pathways involved in energy metabolism during thermoregulation processes in cattle. Objective herein was to study the association between single nucleotide polymorphisms (SNP) within genes of the PRL and GH/IGF-1 pathways with fertility traits such as services per conception (SPC) and days open (DO) in Holstein cattle lactating under a hot-humid climate. Ambient temperature and relative humidity were used to calculate the temperature-humidity index (THI) which revealed that the cows were exposed to heat stress conditions from June to November of 2012 in southern Sonora, Mexico. Individual blood samples from all cows were collected, spotted on FTA cards, and used to genotype a 179 tag SNP panel within 44 genes from the PRL and GH/IGF-1 pathways. The associative analyses among SNP genotypes and fertility traits were performed using mixed-effect models. Allele substitution effects were calculated using a regression model that included the genotype term as covariate. Single-SNP association analyses indicated that eight SNP within the genes
IGF-1
,
IGF-1R
,
IGFBP5
,
PAPPA1
,
PMCH
,
PRLR
,
SOCS5
, and
SSTR2
were associated with SPC (
P
< 0.05), whereas four SNP in the genes
GHR
,
PAPPA2
,
PRLR
, and
SOCS4
were associated with DO (
P
< 0.05). In conclusion, SNP within genes of the PRL and GH/IGF-1 pathways resulted as predictors of reproductive phenotypes in heat-stressed Holstein cows, and these SNP are proposed as candidates for a marker-assisted selection program intended to improve fertility of dairy cattle raised in warm climates.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>29926362</pmid><doi>10.1007/s11250-018-1645-0</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4814-9851</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Tropical animal health and production, 2018-12, Vol.50 (8), p.1913-1920 |
| issn | 0049-4747 1573-7438 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2057869291 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Ambient temperature Biomedical and Life Sciences Bovidae Cattle Dairy cattle Energy metabolism Fertility Genes Genotypes Growth hormones Heat stress Heat tolerance Humid climates Humidity Insulin Insulin-like growth factor I Insulin-like growth factor-binding protein 5 Insulin-like growth factors Life Sciences Marker-assisted selection Metabolism Phenotypes Prolactin Regression analysis Regression models Regular Articles Relative humidity Single-nucleotide polymorphism Thermoregulation Veterinary Medicine/Veterinary Science Zoology |
| title | Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate |
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