Comprehensive Quantification of the Modified Proteome Reveals Oxidative Heart Damage in Mitochondrial Heteroplasmy

Post-translational modifications hugely increase the functional diversity of proteomes. Recent algorithms based on ultratolerant database searching are forging a path to unbiased analysis of peptide modifications by shotgun mass spectrometry. However, these approaches identify only one-half of the m...

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Veröffentlicht in:	Cell reports (Cambridge) 2018-06, Vol.23 (12), p.3685-3697.e4
Hauptverfasser:	Bagwan, Navratan, Bonzon-Kulichenko, Elena, Calvo, Enrique, Lechuga-Vieco, Ana Victoria, Michalakopoulos, Spiros, Trevisan-Herraz, Marco, Ezkurdia, Iakes, Rodríguez, José Manuel, Magni, Ricardo, Latorre-Pellicer, Ana, Enríquez, José Antonio, Vázquez, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bioinformatics HEK293 Cells heteroplasmy Humans Male mass spectrometry Mice, Inbred C57BL mitochondria Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Myocardium - metabolism Myocardium - pathology Oxidative Phosphorylation Oxidative Stress Peptides - metabolism post-translational modifications Protein Processing, Post-Translational Proteome - metabolism proteomics Proteomics - methods
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