Stereoretentive Etherification of an α‑Aryl-β-amino Alcohol Using a Selective Aziridinium Ring Opening for the Synthesis of AZD7594

A selective aziridinium ring-opening was used to etherify an α-aryl-β-amino alcohol with stereochemical retention. This transformation was achieved in a biphasic system to address phenoxide solubility and the formation of a sulfonate ester impurity. The protecting group strategy was directed by a st...

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Veröffentlicht in:	Journal of organic chemistry 2019-04, Vol.84 (8), p.4629-4638
Hauptverfasser:	McMillan, Angus E, Steven, Alan, Ashworth, Ian W, Mullen, Alexander K, Chan, Lai C, Galan Espinosa, Maria Rita, Pilling, Michael J, Raw, Steven A, Jones, Martin F
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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