Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain
Oxytocin has known antinociceptive effects and is upregulated perinatally. This pilot study investigated the association of plasma oxytocin and postcesarean incisional pain. Plasma samples from 18 patients undergoing elective cesarean delivery were drawn at 1 hour preoperatively and 1 and 24 hours p...
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| Veröffentlicht in: | Anesthesia and analgesia 2019-10, Vol.129 (4), p.e118-e121 |
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| container_title | Anesthesia and analgesia |
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| creator | Ende, Holly B. Soens, Mieke A. Nandi, Meghna Strichartz, Gary R. Schreiber, Kristin L. |
| description | Oxytocin has known antinociceptive effects and is upregulated perinatally. This pilot study investigated the association of plasma oxytocin and postcesarean incisional pain. Plasma samples from 18 patients undergoing elective cesarean delivery were drawn at 1 hour preoperatively and 1 and 24 hours postoperatively and analyzed by using enzyme-linked immunosorbent assay. Pain was assessed at 1 day, 8 weeks, 3 months, and 6 months postoperatively. Incisional pain at 24 hours was inversely correlated with 1- and 24-hour oxytocin levels, with higher plasma oxytocin associated with lower pain (
ρ
, −0.52 and −0.66;
P
< .05). |
| doi_str_mv | 10.1213/ANE.0000000000003567 |
| format | Article |
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ρ
, −0.52 and −0.66;
P
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ρ
, −0.52 and −0.66;
P
< .05).</description><subject>Adult</subject><subject>Biological Variation, Population</subject><subject>Biomarkers - blood</subject><subject>Cesarean Section - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Oxytocin - blood</subject><subject>Pain, Postoperative - blood</subject><subject>Pain, Postoperative - diagnosis</subject><subject>Pain, Postoperative - etiology</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Pilot Projects</subject><subject>Pregnancy</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMobk7_gUgvvenM6VeSyzH8GAy3Cz-upKTtKYum7Uxa5_69mZsiXmgghHPyvOfAQ8gp0CEEEF6Mbi-H9McJ44TtkT7EQeKzWPB90t90_UAI0SNH1j67EihPDknP9SDhSdAnTyNrm1zJVjW115TepG7RqLpQb6ropPYepNl9qtqba2kr6c3e163L1N6jahfevLFtjlYalLWL58o62iXnUtXH5KCU2uLJ7h2Q-6vLu_GNP51dT8ajqZ9HEWN-DlEZcCwzLoAVMTAQAJKhoIiUygTDrMhYJDLKkHGRI2SskBHIIonDEHk4IOfbuUvTvHZo27RSNketZY1NZ9OAxgxAMBE7NNqiuWmsNVimS6MqadYp0HQjNnVi099iXexst6HLKiy-Q18mHcC3wKrRTqF90d0KTbpAqdvFf7OjP6KfXBwKP6BOy6bw3XXDPgDQc5Ss</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Ende, Holly B.</creator><creator>Soens, Mieke A.</creator><creator>Nandi, Meghna</creator><creator>Strichartz, Gary R.</creator><creator>Schreiber, Kristin L.</creator><general>International Anesthesia Research Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20191001</creationdate><title>Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain</title><author>Ende, Holly B. ; Soens, Mieke A. ; Nandi, Meghna ; Strichartz, Gary R. ; Schreiber, Kristin L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4477-c14f28efb8917d5171911a7e90ee00a6e3bdb749b07e789ce1b7da41ad6533e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Biological Variation, Population</topic><topic>Biomarkers - blood</topic><topic>Cesarean Section - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Oxytocin - blood</topic><topic>Pain, Postoperative - blood</topic><topic>Pain, Postoperative - diagnosis</topic><topic>Pain, Postoperative - etiology</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Pilot Projects</topic><topic>Pregnancy</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ende, Holly B.</creatorcontrib><creatorcontrib>Soens, Mieke A.</creatorcontrib><creatorcontrib>Nandi, Meghna</creatorcontrib><creatorcontrib>Strichartz, Gary R.</creatorcontrib><creatorcontrib>Schreiber, Kristin L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ende, Holly B.</au><au>Soens, Mieke A.</au><au>Nandi, Meghna</au><au>Strichartz, Gary R.</au><au>Schreiber, Kristin L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>129</volume><issue>4</issue><spage>e118</spage><epage>e121</epage><pages>e118-e121</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><abstract>Oxytocin has known antinociceptive effects and is upregulated perinatally. This pilot study investigated the association of plasma oxytocin and postcesarean incisional pain. Plasma samples from 18 patients undergoing elective cesarean delivery were drawn at 1 hour preoperatively and 1 and 24 hours postoperatively and analyzed by using enzyme-linked immunosorbent assay. Pain was assessed at 1 day, 8 weeks, 3 months, and 6 months postoperatively. Incisional pain at 24 hours was inversely correlated with 1- and 24-hour oxytocin levels, with higher plasma oxytocin associated with lower pain (
ρ
, −0.52 and −0.66;
P
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Biological Variation, Population Biomarkers - blood Cesarean Section - adverse effects Female Humans Oxytocin - blood Pain, Postoperative - blood Pain, Postoperative - diagnosis Pain, Postoperative - etiology Pain, Postoperative - prevention & control Pilot Projects Pregnancy Time Factors Up-Regulation |
| title | Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain |
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