Anti‐Factor H Autoantibodies in a Fifth Renal Transplant Recipient with Atypical Hemolytic and Uremic Syndrome
Hemolytic uremic syndrome (HUS) associated with anti‐Factor H (anti‐FH) autoantibodies is a recently described pathophysiological entity. Monitoring of anti‐FH IgG titer may be a sensitive marker of disease activity and guide treatment to eliminate circulating anti‐FH antibodies. We report here a ca...
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| Veröffentlicht in: | American journal of transplantation 2009-05, Vol.9 (5), p.1223-1229 |
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| container_title | American journal of transplantation |
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| creator | Le Quintrec, M. Zuber, J. Noel, L.‐H. Thervet, E. Frémeaux‐Bacchi, V. Fridman, W.‐H. Legendre, C. Dragon‐Durey, M.‐A. |
| description | Hemolytic uremic syndrome (HUS) associated with anti‐Factor H (anti‐FH) autoantibodies is a recently described pathophysiological entity. Monitoring of anti‐FH IgG titer may be a sensitive marker of disease activity and guide treatment to eliminate circulating anti‐FH antibodies. We report here a case of atypical HUS (aHUS) in which anti‐FH autoantibodies were detected during the course of a fifth kidney transplant, 30 years after the first flare of aHUS. This exceptional case suggests that early, specific management based on immunosuppressive therapy and plasma exchanges monitored by anti‐FH IgG titer may result in long‐term graft survival.
The detection and monitoring of anti Factor‐H auto‐antibodies in an atypical HUS case prevented a relapse in a fifth transplantation. |
| doi_str_mv | 10.1111/j.1600-6143.2009.02586.x |
| format | Article |
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The detection and monitoring of anti Factor‐H auto‐antibodies in an atypical HUS case prevented a relapse in a fifth transplantation.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/j.1600-6143.2009.02586.x</identifier><identifier>PMID: 19422347</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Autoantibodies - blood ; Biological and medical sciences ; Blood Proteins - genetics ; Child ; Complement C3b Inactivator Proteins - genetics ; Complement Factor B - immunology ; Complement Factor H - immunology ; Female ; Gene Deletion ; Hematologic and hematopoietic diseases ; Hemolytic-Uremic Syndrome - classification ; Hemolytic-Uremic Syndrome - immunology ; Hemolytic-Uremic Syndrome - surgery ; Humans ; Kidney Transplantation - immunology ; Medical sciences ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Platelet diseases and coagulopathies ; Recurrence ; Renal failure ; Reoperation - statistics & numerical data ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><ispartof>American journal of transplantation, 2009-05, Vol.9 (5), p.1223-1229</ispartof><rights>2009 The Authors Journal compilation © 2009 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5336-46fd2ca84d68c4977f2b0ce9cdf9beb16e2870deb127631e4eda02bb7744a97a3</citedby><cites>FETCH-LOGICAL-c5336-46fd2ca84d68c4977f2b0ce9cdf9beb16e2870deb127631e4eda02bb7744a97a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-6143.2009.02586.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-6143.2009.02586.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21473891$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19422347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Quintrec, M.</creatorcontrib><creatorcontrib>Zuber, J.</creatorcontrib><creatorcontrib>Noel, L.‐H.</creatorcontrib><creatorcontrib>Thervet, E.</creatorcontrib><creatorcontrib>Frémeaux‐Bacchi, V.</creatorcontrib><creatorcontrib>Fridman, W.‐H.</creatorcontrib><creatorcontrib>Legendre, C.</creatorcontrib><creatorcontrib>Dragon‐Durey, M.‐A.</creatorcontrib><title>Anti‐Factor H Autoantibodies in a Fifth Renal Transplant Recipient with Atypical Hemolytic and Uremic Syndrome</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Hemolytic uremic syndrome (HUS) associated with anti‐Factor H (anti‐FH) autoantibodies is a recently described pathophysiological entity. Monitoring of anti‐FH IgG titer may be a sensitive marker of disease activity and guide treatment to eliminate circulating anti‐FH antibodies. We report here a case of atypical HUS (aHUS) in which anti‐FH autoantibodies were detected during the course of a fifth kidney transplant, 30 years after the first flare of aHUS. This exceptional case suggests that early, specific management based on immunosuppressive therapy and plasma exchanges monitored by anti‐FH IgG titer may result in long‐term graft survival.
The detection and monitoring of anti Factor‐H auto‐antibodies in an atypical HUS case prevented a relapse in a fifth transplantation.</description><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - genetics</subject><subject>Child</subject><subject>Complement C3b Inactivator Proteins - genetics</subject><subject>Complement Factor B - immunology</subject><subject>Complement Factor H - immunology</subject><subject>Female</subject><subject>Gene Deletion</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemolytic-Uremic Syndrome - classification</subject><subject>Hemolytic-Uremic Syndrome - immunology</subject><subject>Hemolytic-Uremic Syndrome - surgery</subject><subject>Humans</subject><subject>Kidney Transplantation - immunology</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Platelet diseases and coagulopathies</subject><subject>Recurrence</subject><subject>Renal failure</subject><subject>Reoperation - statistics & numerical data</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1u2zAQRokiRZO4vULATbOzQlK0KC26EII6bhGgQOusCYocoTT0F1JGol2PkDPmJBnVhrstN_ww88gZPEIoZwnHc7NLeMbYMuMyTQRjRcLEKs-S53fk4tQ4O-V0dU4uY9wxxpXIxQdyzgspRCrVBRnKbvSvf17Wxo59oBta7sfeYK3qnYdIfUcNXft6_E1_Qmcaug2mi0ODCBasHzxgevLYL8dp8BaRDbR9M43eUtM5-hCgxfhr6lzoW_hI3temifDpeC_Iw_rr9nazvP9x9-22vF_aVZpmS5nVTliTS5flVhZK1aJiFgrr6qKCimcgcsUcJqGylIMEZ5ioKqWkNIUy6YJcH_4dQv-4hzjq1kcLDW4O_T5qwVaKM5y1IPkBtKGPMUCth-BbEybNmZ5t652eRepZqp5t67-29TM-vTrO2FctuH8Pj3oR-HwETEQzNbqzPp44wZHJC47clwP35BuY_nsBXX7fzil9A73HnMU</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Le Quintrec, M.</creator><creator>Zuber, J.</creator><creator>Noel, L.‐H.</creator><creator>Thervet, E.</creator><creator>Frémeaux‐Bacchi, V.</creator><creator>Fridman, W.‐H.</creator><creator>Legendre, C.</creator><creator>Dragon‐Durey, M.‐A.</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200905</creationdate><title>Anti‐Factor H Autoantibodies in a Fifth Renal Transplant Recipient with Atypical Hemolytic and Uremic Syndrome</title><author>Le Quintrec, M. ; Zuber, J. ; Noel, L.‐H. ; Thervet, E. ; Frémeaux‐Bacchi, V. ; Fridman, W.‐H. ; Legendre, C. ; Dragon‐Durey, M.‐A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5336-46fd2ca84d68c4977f2b0ce9cdf9beb16e2870deb127631e4eda02bb7744a97a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - genetics</topic><topic>Child</topic><topic>Complement C3b Inactivator Proteins - genetics</topic><topic>Complement Factor B - immunology</topic><topic>Complement Factor H - immunology</topic><topic>Female</topic><topic>Gene Deletion</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemolytic-Uremic Syndrome - classification</topic><topic>Hemolytic-Uremic Syndrome - immunology</topic><topic>Hemolytic-Uremic Syndrome - surgery</topic><topic>Humans</topic><topic>Kidney Transplantation - immunology</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Platelet diseases and coagulopathies</topic><topic>Recurrence</topic><topic>Renal failure</topic><topic>Reoperation - statistics & numerical data</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Quintrec, M.</creatorcontrib><creatorcontrib>Zuber, J.</creatorcontrib><creatorcontrib>Noel, L.‐H.</creatorcontrib><creatorcontrib>Thervet, E.</creatorcontrib><creatorcontrib>Frémeaux‐Bacchi, V.</creatorcontrib><creatorcontrib>Fridman, W.‐H.</creatorcontrib><creatorcontrib>Legendre, C.</creatorcontrib><creatorcontrib>Dragon‐Durey, M.‐A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Quintrec, M.</au><au>Zuber, J.</au><au>Noel, L.‐H.</au><au>Thervet, E.</au><au>Frémeaux‐Bacchi, V.</au><au>Fridman, W.‐H.</au><au>Legendre, C.</au><au>Dragon‐Durey, M.‐A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti‐Factor H Autoantibodies in a Fifth Renal Transplant Recipient with Atypical Hemolytic and Uremic Syndrome</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2009-05</date><risdate>2009</risdate><volume>9</volume><issue>5</issue><spage>1223</spage><epage>1229</epage><pages>1223-1229</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>Hemolytic uremic syndrome (HUS) associated with anti‐Factor H (anti‐FH) autoantibodies is a recently described pathophysiological entity. Monitoring of anti‐FH IgG titer may be a sensitive marker of disease activity and guide treatment to eliminate circulating anti‐FH antibodies. We report here a case of atypical HUS (aHUS) in which anti‐FH autoantibodies were detected during the course of a fifth kidney transplant, 30 years after the first flare of aHUS. This exceptional case suggests that early, specific management based on immunosuppressive therapy and plasma exchanges monitored by anti‐FH IgG titer may result in long‐term graft survival.
The detection and monitoring of anti Factor‐H auto‐antibodies in an atypical HUS case prevented a relapse in a fifth transplantation.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>19422347</pmid><doi>10.1111/j.1600-6143.2009.02586.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Autoantibodies - blood Biological and medical sciences Blood Proteins - genetics Child Complement C3b Inactivator Proteins - genetics Complement Factor B - immunology Complement Factor H - immunology Female Gene Deletion Hematologic and hematopoietic diseases Hemolytic-Uremic Syndrome - classification Hemolytic-Uremic Syndrome - immunology Hemolytic-Uremic Syndrome - surgery Humans Kidney Transplantation - immunology Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Platelet diseases and coagulopathies Recurrence Renal failure Reoperation - statistics & numerical data Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases |
| title | Anti‐Factor H Autoantibodies in a Fifth Renal Transplant Recipient with Atypical Hemolytic and Uremic Syndrome |
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