DHA Selectively Protects SAMP-8-Associated Cognitive Deficits Through Inhibition of JNK

A potential role of marine n-3 polyunsaturated fatty acids (ω-3 PUFAs) has been suggested in memory, learning, and cognitive processes. Therefore, ω-3 PUFAs might be a promising treatment option, albeit controversial, for Alzheimer’s disease (AD). Among the different mechanisms that have been propos...

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Veröffentlicht in:	Molecular neurobiology 2019-03, Vol.56 (3), p.1618-1627
Hauptverfasser:	Vela, S., Sainz, Neira, Moreno-Aliaga, María J., Solas, M., Ramirez, María J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Animals Biomedical and Life Sciences Biomedicine c-Jun protein Cell Biology Cognition - drug effects Cognitive ability Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism Disease Models, Animal Docosahexaenoic acid Docosahexaenoic Acids - pharmacology Docosahexaenoic Acids - therapeutic use Eicosapentaenoic acid Inhibition Learning MAP Kinase Kinase 4 - antagonists & inhibitors MAP Kinase Kinase 4 - metabolism Medical treatment Memory Mice Motor Activity - drug effects Neurobiology Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Pattern recognition Phosphorylation Polyunsaturated fatty acids Recognition, Psychology - drug effects Senescence Signal Transduction - drug effects Spatial Learning - drug effects Tau protein Transcription factors
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