NADPH supply for poly(3-hydroxybutyrate) synthesis concomitant with enzymatic oxidation of phosphite

Acetoacetyl-CoA reductase (PhaB), involved in poly(3-hydroxybutyrate) [P(3HB)] biosynthesis, requires the coenzyme NADPH as a reducing agent. In this study, the effect of NADPH supply on P(3HB) production was investigated in vitro and in vivo using a phosphite dehydrogenase double mutant (PtxDEAAR),...

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Veröffentlicht in:	Journal of bioscience and bioengineering 2018-12, Vol.126 (6), p.764-768
Hauptverfasser:	Miyahara, Yuki, Oota, Mino, Tsuge, Takeharu
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid - metabolism Alcohol Oxidoreductases - metabolism Coenzymes Cofactor regeneration Dose-Response Relationship, Drug Escherichia coli Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli - metabolism Hydroxybutyrates - metabolism NADH, NADPH Oxidoreductases - metabolism NADP - pharmacology NADPH Phosphite dehydrogenase Phosphites - metabolism Polyesters - metabolism Polyhydroxyalkanoates
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