IL-15 and IFN-γ signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling

[Display omitted] •IFN-γ and IL-15 inhibit HCV replication in Huh7.5 cells.•IL-15 and IFN-γ do not induce anti-HCV effects via the type I IFN signaling pathway.•IL-15 and IFN-γ do not induce anti-HCV effects via nitric oxide production.•IL-15 and IFN-γ may provide protection against HCV via the ERK...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2019-12, Vol.124, p.154439-154439, Article 154439
Hauptverfasser:	Vahedi, Fatemeh, Lee, Amanda J., Collins, Susan E., Chew, Marianne V., Lusty, Evan, Chen, Branson, Dubey, Anisha, Richards, Carl D., Feld, Jordan J., Russell, Rodney S., Mossman, Karen L., Ashkar, Ali A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral agents Hepatitis C Interferon type I Interleukin-15 (IL-15) MAP kinase signaling system Natural killer (NK) cells
Online-Zugang:	Volltext
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