Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors

Aromatase enzyme (CYP19) is widely known as a critical target protein for treating hormone-dependent breast cancer. Natural products from traditional medicinal plants continue to be an active source of aromatase inhibitors. Meanwhile, high cost of experimental work and low hit rate associated with H...

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Veröffentlicht in:	Journal of ethnopharmacology 2018-10, Vol.224, p.359-372
Hauptverfasser:	Dawood, Hend M., Ibrahim, Reham S., Shawky, Eman, Hammoda, Hala M., Metwally, Aly M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatase inhibitors Docking Pharmacophore modelling Structure-based and ligand-based virtual screening Traditional Egyptian plants
Online-Zugang:	Volltext
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