Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells

[Display omitted] Nitro-fatty acids (NFAs) are endogenously occurring lipid mediators exerting strong anti-inflammatory effects and acting as anti-oxidants in a number of animal models of inflammation. These NFA effects are mediated by targeting important regulatory proteins involved in inflammatory...

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Veröffentlicht in:Biochemical pharmacology 2018-09, Vol.155, p.48-60
Hauptverfasser: Kühn, Benjamin, Brat, Camilla, Fettel, Jasmin, Hellmuth, Nadine, Maucher, Isabelle V., Bulut, Ufuk, Hock, Katharina J., Grimmer, Jennifer, Manolikakes, Georg, Rühl, Michael, Kühn, Alessa, Zacharowski, Kai, Matrone, Carmela, Urbschat, Anja, Roos, Jessica, Steinhilber, Dieter, Maier, Thorsten J.
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Sprache:eng
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