Developmental Origin Governs CD8+ T Cell Fate Decisions during Infection

Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following infection, naive T cells differentiate into various subsets of effector and memory T cells, which help to eliminate pathogens and maintain long-term immunity. The current model suggests there is a single line...

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Veröffentlicht in:	Cell 2018-06, Vol.174 (1), p.117-130.e14
Hauptverfasser:	Smith, Norah L., Patel, Ravi K., Reynaldi, Arnold, Grenier, Jennifer K., Wang, Jocelyn, Watson, Neva B., Nzingha, Kito, Yee Mon, Kristel J., Peng, Seth A., Grimson, Andrew, Davenport, Miles P., Rudd, Brian D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8+ T cell CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Differentiation Cell Line, Tumor Chromatin - metabolism Cytokines - pharmacology development effector cell differentiation epigenetics Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - metabolism Genes, Developmental homeostatic proliferation immune ontogeny Immunologic Memory immunological memory Interferon-gamma - metabolism Killer Cells, Natural - cytology Killer Cells, Natural - metabolism Listeria monocytogenes - metabolism Listeria monocytogenes - pathogenicity Mice Mice, Inbred C57BL neonate post-thymic maturation Principal Component Analysis T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Thymus Gland - transplantation Transcription Factors - genetics Transcription Factors - metabolism Transcriptome virtual memory cells
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