Neuronal complement cascade drives bone cancer pain via C3R mediated microglial activation

•Neuronal-derived complement pathway drived the development of BCP.•Complements activated C3R in the microglia druing the development of BCP.•Complements promoted the proliferation of microglia via C3R. Activation of spinal cord microglia is crucial for the development of bone cancer pain (BCP). The...

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Veröffentlicht in:	Brain research 2018-11, Vol.1698, p.81-88
Hauptverfasser:	Huang, Xiaoxia, Li, Jinyuan, Xie, Jin, Li, Yang, Gao, Yan, Li, Xiaohui, Xu, Xueqin, Shi, Ruoshi, Yao, Wanjun, Ke, Changbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone cancer pain Complement pathway Complement receptor Microglia
Online-Zugang:	Volltext
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