Protective Effects of Shenfu Injection against Myocardial Ischemia–Reperfusion Injury via Activation of eNOS in Rats

The aim of the present study was to investigate the protective effects of Shenfu injection (SFI) against myocardial ischemia–reperfusion injury (MIRI) in model rats and to explore its mechanism of action. Sprague–Dawley (SD) rats were pretreated with SFI and NG-nitro-L-arginine methyl ester (L-NAME)...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2018/09/01, Vol.41(9), pp.1406-1413
Hauptverfasser:	Wang, Yan-yan, Li, Yan-yan, Li, Lin, Yang, Dong-li, Zhou, Kun, Li, Yu-hong
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Arginine Blood pressure Calcium-binding protein Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Cerebral infarction Coronary artery Creatine Creatine kinase Diastolic pressure Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Echocardiography Ejection Enzyme Activation - drug effects Enzyme Activation - physiology Heart Hemodynamics Injection Ischemia ischemia reperfusion injury L-Lactate dehydrogenase Lactic acid left ventricular function Male Myocardial infarction Myocardial ischemia Myocardial Reperfusion Injury - diagnostic imaging Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - prevention & control NG-nitro-L-arginine methyl ester (L-NAME) NG-Nitroarginine methyl ester Nitric oxide Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Occlusion Phosphorylation Rats Rats, Sprague-Dawley Reperfusion Rodents Shenfu injection Stroke volume Systolic pressure Treatment Outcome Troponin Ventricle Western blotting
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