Effects of increasing doses of samarium-153-ethylenediaminetetramethylene phosphonate on axial and appendicular skeletal growth in juvenile rabbits

Abstract Introduction Targeted radiotherapy using samarium-153-ethylenediaminetetramethylene phosphonate (153 Sm-EDTMP) is currently under investigation for treatment of osteosarcoma. Osteosarcoma often occurs in children, and previous studies on a juvenile rabbit model demonstrated that clinically...

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Veröffentlicht in:	Nuclear medicine and biology 2008-02, Vol.35 (2), p.219-225
Hauptverfasser:	Essman, Stephanie C, Lewis, Michael R, Fox, Derek B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone and Bones - diagnostic imaging Bone and Bones - radiation effects Bone Development - radiation effects Bone growth Dose-Response Relationship, Radiation Female Growth Plate - diagnostic imaging Growth Plate - radiation effects Organophosphonates - pharmacokinetics Osteosarcoma Physeal cartilage Rabbits Radioisotopes - adverse effects Radioisotopes - pharmacokinetics Radiology Radionuclide Imaging Radiopharmaceuticals - adverse effects Radiopharmaceuticals - pharmacokinetics Radiotherapy Dosage Samarium - pharmacokinetics Samarium-153-ethylenediaminetetramethylene phosphonate
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