Sigma receptor ligands protect human retinal cells against oxidative stress
This study was undertaken to investigate the role of σ receptors during the oxidative damage on human retinal pigment epithelial cells, and to assess whether σ receptor ligands enhance survival and protect DNA of cells challenged by oxidative stress. Pretreatment with PRE-084, a σ1 receptor agonist,...
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| Veröffentlicht in: | Neuroreport 2006-02, Vol.17 (3), p.287-291 |
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| creator | Bucolo, Claudio Drago, Filippo Lin, Li-Ren Reddy, Venkat N |
| description | This study was undertaken to investigate the role of σ receptors during the oxidative damage on human retinal pigment epithelial cells, and to assess whether σ receptor ligands enhance survival and protect DNA of cells challenged by oxidative stress. Pretreatment with PRE-084, a σ1 receptor agonist, resulted in significant increased viability in a dose-related manner. DNA damage induced by oxidative insult was significantly lower with PRE-084. The effects of PRE-084 were antagonized by pretreatment with σ1 receptor antagonists (NE-100 and BD1047), but interestingly were synergized by cotreatment with BD1047 that also presented an affinity for the σ2 receptor. The results suggest that σ1 receptors play an important role against retinal damage, even though σ2 receptor involvement cannot be excluded. |
| doi_str_mv | 10.1097/01.wnr.0000199469.21734.e1 |
| format | Article |
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Pretreatment with PRE-084, a σ1 receptor agonist, resulted in significant increased viability in a dose-related manner. DNA damage induced by oxidative insult was significantly lower with PRE-084. The effects of PRE-084 were antagonized by pretreatment with σ1 receptor antagonists (NE-100 and BD1047), but interestingly were synergized by cotreatment with BD1047 that also presented an affinity for the σ2 receptor. 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Psychology ; Humans ; Hydrogen Peroxide - adverse effects ; Morpholines - pharmacology ; Oxidative Stress - drug effects ; Propylamines - pharmacology ; Receptors, sigma - agonists ; Receptors, sigma - antagonists & inhibitors ; Receptors, sigma - physiology ; Retina - cytology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2006-02, Vol.17 (3), p.287-291</ispartof><rights>2006 Lippincott Williams & Wilkins, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4232-36d74e72e645dbf205d57bd84337c377d0aa39a178086a123547f092edcf47d83</citedby><cites>FETCH-LOGICAL-c4232-36d74e72e645dbf205d57bd84337c377d0aa39a178086a123547f092edcf47d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17701368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16462599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bucolo, Claudio</creatorcontrib><creatorcontrib>Drago, Filippo</creatorcontrib><creatorcontrib>Lin, Li-Ren</creatorcontrib><creatorcontrib>Reddy, Venkat N</creatorcontrib><title>Sigma receptor ligands protect human retinal cells against oxidative stress</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>This study was undertaken to investigate the role of σ receptors during the oxidative damage on human retinal pigment epithelial cells, and to assess whether σ receptor ligands enhance survival and protect DNA of cells challenged by oxidative stress. Pretreatment with PRE-084, a σ1 receptor agonist, resulted in significant increased viability in a dose-related manner. DNA damage induced by oxidative insult was significantly lower with PRE-084. The effects of PRE-084 were antagonized by pretreatment with σ1 receptor antagonists (NE-100 and BD1047), but interestingly were synergized by cotreatment with BD1047 that also presented an affinity for the σ2 receptor. The results suggest that σ1 receptors play an important role against retinal damage, even though σ2 receptor involvement cannot be excluded.</description><subject>Anisoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>DNA Damage - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Epithelial Cells - drug effects</subject><subject>Ethylenediamines - pharmacology</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hydrogen Peroxide - adverse effects</subject><subject>Morpholines - pharmacology</subject><subject>Oxidative Stress - drug effects</subject><subject>Propylamines - pharmacology</subject><subject>Receptors, sigma - agonists</subject><subject>Receptors, sigma - antagonists & inhibitors</subject><subject>Receptors, sigma - physiology</subject><subject>Retina - cytology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1vEzEQhi0EomnhL6AVEr3t1t9ec0NVS1ErcQAkbpZjzyYG726wvQT-PQ6JlLlYGj8z8-pB6C3BHcFa3WDS7afU4VpEay51R4livAPyDK0IV6wVov_-HK2wFrrlWooLdJnzj8prTPqX6IJILqnQeoUev4TNaJsEDnZlTk0MGzv53OzSXMCVZruMdqrfJUw2Ng5izI3d2DDl0sx_grcl_IYmlwQ5v0IvBhszvD69V-jb_d3X24f26fPHT7cfnlrHKaMtk15xUBQkF349UCy8UGvfc8aUY0p5bC3Tlqge99ISygRXA9YUvBu48j27QtfHvTXkrwVyMWPIh2h2gnnJpm6UQkhewfdH0KU55wSD2aUw2vTXEGwOKg0mpqo0Z5Xmv0oDpA6_OV1Z1iP48-jJXQXenQCbnY1DspML-cwphQmTh7j8yO3nWCDln3HZQzJbsLFsj6eVkC3FWGJKFW4PHcr-AcXvjZQ</recordid><startdate>20060227</startdate><enddate>20060227</enddate><creator>Bucolo, Claudio</creator><creator>Drago, Filippo</creator><creator>Lin, Li-Ren</creator><creator>Reddy, Venkat N</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20060227</creationdate><title>Sigma receptor ligands protect human retinal cells against oxidative stress</title><author>Bucolo, Claudio ; Drago, Filippo ; Lin, Li-Ren ; Reddy, Venkat N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4232-36d74e72e645dbf205d57bd84337c377d0aa39a178086a123547f092edcf47d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anisoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>DNA Damage - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Epithelial Cells - drug effects</topic><topic>Ethylenediamines - pharmacology</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hydrogen Peroxide - adverse effects</topic><topic>Morpholines - pharmacology</topic><topic>Oxidative Stress - drug effects</topic><topic>Propylamines - pharmacology</topic><topic>Receptors, sigma - agonists</topic><topic>Receptors, sigma - antagonists & inhibitors</topic><topic>Receptors, sigma - physiology</topic><topic>Retina - cytology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bucolo, Claudio</creatorcontrib><creatorcontrib>Drago, Filippo</creatorcontrib><creatorcontrib>Lin, Li-Ren</creatorcontrib><creatorcontrib>Reddy, Venkat N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bucolo, Claudio</au><au>Drago, Filippo</au><au>Lin, Li-Ren</au><au>Reddy, Venkat N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sigma receptor ligands protect human retinal cells against oxidative stress</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2006-02-27</date><risdate>2006</risdate><volume>17</volume><issue>3</issue><spage>287</spage><epage>291</epage><pages>287-291</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>This study was undertaken to investigate the role of σ receptors during the oxidative damage on human retinal pigment epithelial cells, and to assess whether σ receptor ligands enhance survival and protect DNA of cells challenged by oxidative stress. Pretreatment with PRE-084, a σ1 receptor agonist, resulted in significant increased viability in a dose-related manner. DNA damage induced by oxidative insult was significantly lower with PRE-084. The effects of PRE-084 were antagonized by pretreatment with σ1 receptor antagonists (NE-100 and BD1047), but interestingly were synergized by cotreatment with BD1047 that also presented an affinity for the σ2 receptor. The results suggest that σ1 receptors play an important role against retinal damage, even though σ2 receptor involvement cannot be excluded.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>16462599</pmid><doi>10.1097/01.wnr.0000199469.21734.e1</doi><tpages>5</tpages></addata></record> |
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| subjects | Anisoles - pharmacology Biological and medical sciences Cell Survival - drug effects Cells, Cultured DNA Damage - drug effects Dose-Response Relationship, Drug Drug Interactions Epithelial Cells - drug effects Ethylenediamines - pharmacology Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Humans Hydrogen Peroxide - adverse effects Morpholines - pharmacology Oxidative Stress - drug effects Propylamines - pharmacology Receptors, sigma - agonists Receptors, sigma - antagonists & inhibitors Receptors, sigma - physiology Retina - cytology Vertebrates: nervous system and sense organs |
| title | Sigma receptor ligands protect human retinal cells against oxidative stress |
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