Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis

Accumulation of misfolded proteins and protein assemblies is associated with neuronal dysfunction and death in several neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease (HD). It is therefore critical to understand the molecular mechanisms of drugs t...

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Veröffentlicht in:	Molecular pharmacology 2008-04, Vol.73 (4), p.1052-1063
Hauptverfasser:	King, Matthew A, Hands, Sarah, Hafiz, Farida, Mizushima, Noboru, Tolkovsky, Aviva M, Wyttenbach, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Autophagy - drug effects Autophagy-Related Protein 5 Cells, Cultured Cycloheximide - pharmacology Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gene Deletion Green Fluorescent Proteins - metabolism Humans Huntingtin Protein Inclusion Bodies - metabolism Mice Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - metabolism Nerve Tissue Proteins - metabolism Nuclear Proteins - metabolism Peptides - chemistry Peptides - metabolism Protein Biosynthesis - drug effects Protein Structure, Quaternary Protein Transport - drug effects Recombinant Fusion Proteins - metabolism Sirolimus - pharmacology Sodium Dodecyl Sulfate - pharmacology Solubility - drug effects Ubiquitin - metabolism Vimentin - metabolism
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