Molecular Interactions of CCR5 with Major Classes of Small-Molecule Anti-HIV CCR5 Antagonists

In addition to being an important receptor in leukocyte activation and mobilization, CCR5 is the essential coreceptor for human immunodeficiency virus (HIV). A large number of small-molecule CCR5 antagonists have been reported that show potent activities in blocking chemokine function and HIV entry....

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Veröffentlicht in:	Molecular pharmacology 2008-03, Vol.73 (3), p.789-800
Hauptverfasser:	Kondru, Rama, Zhang, Jun, Ji, Changhua, Mirzadegan, Tara, Rotstein, David, Sankuratri, Surya, Dioszegi, Marianna
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - metabolism Amides - pharmacology Amino Acid Sequence Animals Anti-HIV Agents - chemistry Anti-HIV Agents - classification Anti-HIV Agents - metabolism Anti-HIV Agents - pharmacology Benzoates - chemistry Benzoates - metabolism Benzoates - pharmacology Binding Sites CCR5 Receptor Antagonists CHO Cells Cricetinae Cricetulus Cyclohexanes - chemistry Cyclohexanes - metabolism Cyclohexanes - pharmacology HIV Fusion Inhibitors - pharmacology HIV-1 - drug effects Human immunodeficiency virus Humans Hydrophobic and Hydrophilic Interactions Inhibitory Concentration 50 Membrane Fusion - drug effects Models, Molecular Molecular Sequence Data Molecular Structure Mutagenesis, Site-Directed Piperazines - chemistry Piperazines - metabolism Piperazines - pharmacology Piperidines - chemistry Piperidines - metabolism Piperidines - pharmacology Protein Structure, Secondary Protein Structure, Tertiary Pyrimidines - chemistry Pyrimidines - metabolism Pyrimidines - pharmacology Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - metabolism Quaternary Ammonium Compounds - pharmacology Radioligand Assay Receptors, CCR5 - chemistry Receptors, CCR5 - genetics Receptors, CCR5 - metabolism Sequence Homology, Amino Acid Spiro Compounds - chemistry Spiro Compounds - metabolism Spiro Compounds - pharmacology Static Electricity Transfection Triazoles - chemistry Triazoles - metabolism Triazoles - pharmacology
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