Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1‐glucosylation kinetics are decisive for cell fate

Toxin A and Toxin B (TcdA/TcdB) are large glucosyltransferases produced by Clostridium difficile. TcdB but not TcdA induces reactive oxygen species‐mediated early cell death (ECD) when applied at high concentrations. We found that nonglucosylated Rac1 is essential for induction of ECD since inhibiti...

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Veröffentlicht in:	Cellular microbiology 2018-10, Vol.20 (10), p.e12865-n/a
Hauptverfasser:	Beer, Lara‐Antonia, Tatge, Helma, Reich, Nicole, Tenspolde, Michel, Olling, Alexandra, Goy, Sebastian, Rottner, Klemens, Alekov, Alexi Kirilov, Gerhard, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Anion exchanging Apoptosis Apoptosis - physiology Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Toxins - genetics Bacterial Toxins - metabolism Cell death Cell fate Cell Line cellular uptake Chimeras Clostridium difficile Clostridium difficile - pathogenicity Cytosol Cytotoxicity Endosomes Glucosyltransferase Glycosylation HEK293 Cells Humans Inhibition Kinetics Na+/H+-exchanging ATPase Proton-Translocating ATPases - metabolism Protons rac1 GTP-Binding Protein - metabolism Rac1 protein Reaction kinetics Reactive oxygen species Reactive Oxygen Species - metabolism Sodium Sodium-Hydrogen Exchangers - metabolism Toxicity Toxin A Toxin B toxins Transfection
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