Establishing the Production of Male Schistosoma mansoni Cercariae for a Controlled Human Infection Model
To accelerate the development of novel vaccines for schistosomiasis, we set out to develop a human model for Schistosoma mansoni infection in healthy volunteers. During natural infections, female schistosomes produce eggs that give rise to morbidity. Therefore, we produced single-sex, male Schistoso...
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| Veröffentlicht in: | The Journal of infectious diseases 2018-08, Vol.218 (7), p.1142-1146 |
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| container_title | The Journal of infectious diseases |
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| creator | Janse, Jacqueline J Langenberg, Marijke C C Kos-Van Oosterhoud, Janneke Ozir-Fazalalikhan, Arifa Brienen, Eric A T Winkel, Béatrice M F Erkens, Marianne A A van der Beek, Martha T van Lieshout, Lisette Smits, Hermelijn H Webster, Bonnie L Zandvliet, Maarten L Verbeek, Richard Westra, Inge M Meij, Pauline Visser, Leo G van Diepen, Angela Hokke, Cornelis H Yazdanbakhsh, Maria Roestenberg, Meta |
| description | To accelerate the development of novel vaccines for schistosomiasis, we set out to develop a human model for Schistosoma mansoni infection in healthy volunteers. During natural infections, female schistosomes produce eggs that give rise to morbidity. Therefore, we produced single-sex, male Schistosoma mansoni cercariae for human infection without egg production and associated pathology. Cercariae were produced in their intermediate snail hosts in accordance with the principles of good manufacturing practice (GMP). The application of GMP principles to an unconventional production process is a showcase for the controlled production of complex live challenge material in the European Union or under Food and Drug Administration guidance. |
| doi_str_mv | 10.1093/infdis/jiy275 |
| format | Article |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| title | Establishing the Production of Male Schistosoma mansoni Cercariae for a Controlled Human Infection Model |
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