Intestinal microbiota assessment in cirrhotic patients from a Mexican mestizo population
The intestinal microbiota is significantly altered in cirrhotic patients, but the composition of the intestinal microbiota in Mexican patients with the pathology has not been reported. The present study is an attempt to determine the type of intestinal microbiota in healthy subjects and in patients...
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| Veröffentlicht in: | Revista de Gastroenterología de México (English Edition) 2019-01, Vol.84 (1), p.26-35 |
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| container_title | Revista de Gastroenterología de México (English Edition) |
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| creator | Pérez-Monter, C Escalona-Nandez, I Estanes-Hernández, A Noriega-López, L G Torre-Delgadillo, A |
| description | The intestinal microbiota is significantly altered in cirrhotic patients, but the composition of the intestinal microbiota in Mexican patients with the pathology has not been reported. The present study is an attempt to determine the type of intestinal microbiota in healthy subjects and in patients of Mexican mestizo origin that present with cirrhosis of the liver.
Biochemical liver function parameters (ALT, AST, GGT, BIL-T, etc.) were determined in 23 cirrhotic patients and 21 control subjects. The intestinal microbiota was established through 16S ribosomal RNA gene sequencing.
The cirrhotic patients had elevated levels of ALT, AST, GGT (105.2±77.7 vs. 20.99±8.5UI/L, 110±68.6 vs. 23.39±5.2, and 119.1±79.1 vs. 19.3±15.2UI/L, respectively), IL-6 (1.64±0.38pg/ml, P |
| doi_str_mv | 10.1016/j.rgmx.2018.02.010 |
| format | Article |
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Biochemical liver function parameters (ALT, AST, GGT, BIL-T, etc.) were determined in 23 cirrhotic patients and 21 control subjects. The intestinal microbiota was established through 16S ribosomal RNA gene sequencing.
The cirrhotic patients had elevated levels of ALT, AST, GGT (105.2±77.7 vs. 20.99±8.5UI/L, 110±68.6 vs. 23.39±5.2, and 119.1±79.1 vs. 19.3±15.2UI/L, respectively), IL-6 (1.64±0.38pg/ml, P<.001), or TNFα (1.78±0.3, P<.05). The intestinal microbiota of the cirrhotic patients was less diverse, compared with that of the control subjects. At the level of the phylum, there was a significant increase in Proteobacteria and Bacteroidetes in the patients with cirrhosis, compared with the controls (6.2 vs. 4.9% and 44 vs. 46%, respectively, P<.01). In contrast, there was a decrease in Firmicutes, Actinobacteria, and Fusobacteria in the cirrhotic patients. There was an increase in the Campylobacter and Gemella families in the cirrhotic patients, whereas Streptococcus and Veillonella had a positive association with serum ALT or AST levels.
To the best of our knowledge, the present study is the first to demonstrate the type of intestinal microbiota in Mexican patients with cirrhosis of the liver. The extension of the findings in a larger cohort of subjects and the metagenome analysis will enable the creation of data that can have relevant treatment implications for this group of patients in Mexico.</description><identifier>ISSN: 0375-0906</identifier><identifier>EISSN: 2255-534X</identifier><identifier>DOI: 10.1016/j.rgmx.2018.02.010</identifier><identifier>PMID: 29903529</identifier><language>eng ; spa</language><publisher>Mexico</publisher><subject>Adult ; Bacterial Load ; DNA, Bacterial - genetics ; Feces - microbiology ; Female ; Gastrointestinal Microbiome ; Humans ; Indians, Central American ; Liver Cirrhosis - microbiology ; Liver Function Tests ; Male ; Mexico ; Middle Aged ; RNA, Ribosomal, 16S - genetics</subject><ispartof>Revista de Gastroenterología de México (English Edition), 2019-01, Vol.84 (1), p.26-35</ispartof><rights>Copyright © 2018 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29903529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez-Monter, C</creatorcontrib><creatorcontrib>Escalona-Nandez, I</creatorcontrib><creatorcontrib>Estanes-Hernández, A</creatorcontrib><creatorcontrib>Noriega-López, L G</creatorcontrib><creatorcontrib>Torre-Delgadillo, A</creatorcontrib><title>Intestinal microbiota assessment in cirrhotic patients from a Mexican mestizo population</title><title>Revista de Gastroenterología de México (English Edition)</title><addtitle>Rev Gastroenterol Mex</addtitle><description>The intestinal microbiota is significantly altered in cirrhotic patients, but the composition of the intestinal microbiota in Mexican patients with the pathology has not been reported. The present study is an attempt to determine the type of intestinal microbiota in healthy subjects and in patients of Mexican mestizo origin that present with cirrhosis of the liver.
Biochemical liver function parameters (ALT, AST, GGT, BIL-T, etc.) were determined in 23 cirrhotic patients and 21 control subjects. The intestinal microbiota was established through 16S ribosomal RNA gene sequencing.
The cirrhotic patients had elevated levels of ALT, AST, GGT (105.2±77.7 vs. 20.99±8.5UI/L, 110±68.6 vs. 23.39±5.2, and 119.1±79.1 vs. 19.3±15.2UI/L, respectively), IL-6 (1.64±0.38pg/ml, P<.001), or TNFα (1.78±0.3, P<.05). The intestinal microbiota of the cirrhotic patients was less diverse, compared with that of the control subjects. At the level of the phylum, there was a significant increase in Proteobacteria and Bacteroidetes in the patients with cirrhosis, compared with the controls (6.2 vs. 4.9% and 44 vs. 46%, respectively, P<.01). In contrast, there was a decrease in Firmicutes, Actinobacteria, and Fusobacteria in the cirrhotic patients. There was an increase in the Campylobacter and Gemella families in the cirrhotic patients, whereas Streptococcus and Veillonella had a positive association with serum ALT or AST levels.
To the best of our knowledge, the present study is the first to demonstrate the type of intestinal microbiota in Mexican patients with cirrhosis of the liver. The extension of the findings in a larger cohort of subjects and the metagenome analysis will enable the creation of data that can have relevant treatment implications for this group of patients in Mexico.</description><subject>Adult</subject><subject>Bacterial Load</subject><subject>DNA, Bacterial - genetics</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastrointestinal Microbiome</subject><subject>Humans</subject><subject>Indians, Central American</subject><subject>Liver Cirrhosis - microbiology</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Mexico</subject><subject>Middle Aged</subject><subject>RNA, Ribosomal, 16S - genetics</subject><issn>0375-0906</issn><issn>2255-534X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LxDAYhIMo7rr6BzxIjl5a37xpku1RFj8WVrwo7K2k2VSzNE1NWlj99VbU08DwMMwMIZcMcgZM3uzz-OYPOQJb5oA5MDgic0QhMsGL7TGZA1cigxLkjJyltAcAuQQ8JTMsS-ACyznZrrvBpsF1uqXemRhqFwZNdUo2JW-7gbqOGhfjexicob0e3GQm2sTgqaZP9uCM7qj_yfgKtA_92E5M6M7JSaPbZC_-dEFe7-9eVo_Z5vlhvbrdZD0yNmSyrFXTMF0s0ShlCiZ3jeClkAJVgZopbhqt6lobRG6hlhxtiWhMzXalmtAFuf7N7WP4GKcalXfJ2LbVnQ1jqhCE5NNcgRN69YeOtbe7qo_O6_hZ_b_BvwFDYmQz</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Pérez-Monter, C</creator><creator>Escalona-Nandez, I</creator><creator>Estanes-Hernández, A</creator><creator>Noriega-López, L G</creator><creator>Torre-Delgadillo, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201901</creationdate><title>Intestinal microbiota assessment in cirrhotic patients from a Mexican mestizo population</title><author>Pérez-Monter, C ; Escalona-Nandez, I ; Estanes-Hernández, A ; Noriega-López, L G ; Torre-Delgadillo, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-69b7ff1a482c77c416df5395652742a173cfa7bbac223e0b632e922ccb1d97f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; spa</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Bacterial Load</topic><topic>DNA, Bacterial - genetics</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastrointestinal Microbiome</topic><topic>Humans</topic><topic>Indians, Central American</topic><topic>Liver Cirrhosis - microbiology</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Mexico</topic><topic>Middle Aged</topic><topic>RNA, Ribosomal, 16S - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pérez-Monter, C</creatorcontrib><creatorcontrib>Escalona-Nandez, I</creatorcontrib><creatorcontrib>Estanes-Hernández, A</creatorcontrib><creatorcontrib>Noriega-López, L G</creatorcontrib><creatorcontrib>Torre-Delgadillo, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista de Gastroenterología de México (English Edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez-Monter, C</au><au>Escalona-Nandez, I</au><au>Estanes-Hernández, A</au><au>Noriega-López, L G</au><au>Torre-Delgadillo, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal microbiota assessment in cirrhotic patients from a Mexican mestizo population</atitle><jtitle>Revista de Gastroenterología de México (English Edition)</jtitle><addtitle>Rev Gastroenterol Mex</addtitle><date>2019-01</date><risdate>2019</risdate><volume>84</volume><issue>1</issue><spage>26</spage><epage>35</epage><pages>26-35</pages><issn>0375-0906</issn><eissn>2255-534X</eissn><abstract>The intestinal microbiota is significantly altered in cirrhotic patients, but the composition of the intestinal microbiota in Mexican patients with the pathology has not been reported. The present study is an attempt to determine the type of intestinal microbiota in healthy subjects and in patients of Mexican mestizo origin that present with cirrhosis of the liver.
Biochemical liver function parameters (ALT, AST, GGT, BIL-T, etc.) were determined in 23 cirrhotic patients and 21 control subjects. The intestinal microbiota was established through 16S ribosomal RNA gene sequencing.
The cirrhotic patients had elevated levels of ALT, AST, GGT (105.2±77.7 vs. 20.99±8.5UI/L, 110±68.6 vs. 23.39±5.2, and 119.1±79.1 vs. 19.3±15.2UI/L, respectively), IL-6 (1.64±0.38pg/ml, P<.001), or TNFα (1.78±0.3, P<.05). The intestinal microbiota of the cirrhotic patients was less diverse, compared with that of the control subjects. At the level of the phylum, there was a significant increase in Proteobacteria and Bacteroidetes in the patients with cirrhosis, compared with the controls (6.2 vs. 4.9% and 44 vs. 46%, respectively, P<.01). In contrast, there was a decrease in Firmicutes, Actinobacteria, and Fusobacteria in the cirrhotic patients. There was an increase in the Campylobacter and Gemella families in the cirrhotic patients, whereas Streptococcus and Veillonella had a positive association with serum ALT or AST levels.
To the best of our knowledge, the present study is the first to demonstrate the type of intestinal microbiota in Mexican patients with cirrhosis of the liver. The extension of the findings in a larger cohort of subjects and the metagenome analysis will enable the creation of data that can have relevant treatment implications for this group of patients in Mexico.</abstract><cop>Mexico</cop><pmid>29903529</pmid><doi>10.1016/j.rgmx.2018.02.010</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Bacterial Load DNA, Bacterial - genetics Feces - microbiology Female Gastrointestinal Microbiome Humans Indians, Central American Liver Cirrhosis - microbiology Liver Function Tests Male Mexico Middle Aged RNA, Ribosomal, 16S - genetics |
| title | Intestinal microbiota assessment in cirrhotic patients from a Mexican mestizo population |
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