Differential effects of typical and atypical antipsychotics on astroglial cells in vitro

•Antipsychotics modulate glial functionality.•Risperidone presented anti-inflammatory effects in astroglial cells.•Haloperidol induced inflammatory response.•p38 MAPK/NFκB signaling was involved in haloperidol-induced inflammatory response. Astrocytes are glial cells that are essential for the maint...

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Veröffentlicht in:	International journal of developmental neuroscience 2018-10, Vol.69 (1), p.1-9
Hauptverfasser:	Bobermin, Larissa Daniele, da Silva, Amanda, Souza, Diogo Onofre, Quincozes-Santos, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antioxidants Antipsychotic Agents - pharmacology Antipsychotics Astrocytes Astrocytes - drug effects Astrocytes - ultrastructure Astroglial cells Behavior disorders Cell Membrane - drug effects Central nervous system Cytokines Cytokines - metabolism Cytoskeleton - drug effects Cytoskeleton - ultrastructure Disorders Extracellular levels Glial cells Glutathione Glutathione - metabolism Haloperidol Haloperidol - pharmacology Heme Oxygenase-1 - biosynthesis Inflammation Inflammatory response Interleukin 1 Interleukin 10 Interleukin 6 MAP kinase Mental disorders Nervous system Neurotransmitters NF-kappa B - biosynthesis NF-κB protein p38 Mitogen-Activated Protein Kinases - biosynthesis Protein kinase Proteins Rats Risperidone Risperidone - pharmacology Transcription Tumor necrosis factor-α
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