Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies

•RPE epithelial barrier features play a key part in rethinopathies.•Adult human RPE cultured cells can express neuronal markers.•HRPE cells customized for tracking processes related to retinal diseases.•SVCT2, GLUTs, MRPs, OR51E2 are targets in cell-based therapies and drug delivery.•RARβ is a topic...

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Veröffentlicht in:	Drug discovery today 2018-09, Vol.23 (9), p.1672-1679
Hauptverfasser:	Pavan, Barbara, Dalpiaz, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Ophthalmic Animals Cell Line Drug Delivery Systems Drug Discovery - methods Gene Expression Regulation Gene Transfer Techniques Genotype Humans Molecular Targeted Therapy Phenotype Retinal Diseases - genetics Retinal Diseases - metabolism Retinal Diseases - pathology Retinal Diseases - therapy Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Signal Transduction - drug effects
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