Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies
•RPE epithelial barrier features play a key part in rethinopathies.•Adult human RPE cultured cells can express neuronal markers.•HRPE cells customized for tracking processes related to retinal diseases.•SVCT2, GLUTs, MRPs, OR51E2 are targets in cell-based therapies and drug delivery.•RARβ is a topic...
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| Veröffentlicht in: | Drug discovery today 2018-09, Vol.23 (9), p.1672-1679 |
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| container_title | Drug discovery today |
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| creator | Pavan, Barbara Dalpiaz, Alessandro |
| description | •RPE epithelial barrier features play a key part in rethinopathies.•Adult human RPE cultured cells can express neuronal markers.•HRPE cells customized for tracking processes related to retinal diseases.•SVCT2, GLUTs, MRPs, OR51E2 are targets in cell-based therapies and drug delivery.•RARβ is a topic for renewal of retinal dopaminergic precursors in RPE cells.
Retinal pigment epithelium (RPE) is a cell monolayer essential for photoreceptor function and forming the blood–retinal barrier. RPE and retinal neurons share the same origin and a polarized cytoarchitecture. Several factors determine the phagocytosis and permeability of RPE, influencing photoreceptor renewal and drug delivery, efficacy and toxicity. Adult human RPE expresses neuronal markers in vitro, indicating a potential transdifferentiation. Degeneration of the RPE leads to death of photoreceptors and retinal neurons, resulting in the vision loss of retinopathy. Here, we suggest tools for cell engineering to discover new ways for activating the endogenous regeneration of barrier functions and/or of the retinal precursors in RPE cells. |
| doi_str_mv | 10.1016/j.drudis.2018.06.009 |
| format | Article |
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Retinal pigment epithelium (RPE) is a cell monolayer essential for photoreceptor function and forming the blood–retinal barrier. RPE and retinal neurons share the same origin and a polarized cytoarchitecture. Several factors determine the phagocytosis and permeability of RPE, influencing photoreceptor renewal and drug delivery, efficacy and toxicity. Adult human RPE expresses neuronal markers in vitro, indicating a potential transdifferentiation. Degeneration of the RPE leads to death of photoreceptors and retinal neurons, resulting in the vision loss of retinopathy. Here, we suggest tools for cell engineering to discover new ways for activating the endogenous regeneration of barrier functions and/or of the retinal precursors in RPE cells.</description><identifier>ISSN: 1359-6446</identifier><identifier>EISSN: 1878-5832</identifier><identifier>DOI: 10.1016/j.drudis.2018.06.009</identifier><identifier>PMID: 29908265</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Administration, Ophthalmic ; Animals ; Cell Line ; Drug Delivery Systems ; Drug Discovery - methods ; Gene Expression Regulation ; Gene Transfer Techniques ; Genotype ; Humans ; Molecular Targeted Therapy ; Phenotype ; Retinal Diseases - genetics ; Retinal Diseases - metabolism ; Retinal Diseases - pathology ; Retinal Diseases - therapy ; Retinal Pigment Epithelium - drug effects ; Retinal Pigment Epithelium - metabolism ; Retinal Pigment Epithelium - pathology ; Signal Transduction - drug effects</subject><ispartof>Drug discovery today, 2018-09, Vol.23 (9), p.1672-1679</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-855e571055a1c494c517db4c127d16b75e2f9b265caf33796b99fad4cd5f031b3</citedby><cites>FETCH-LOGICAL-c474t-855e571055a1c494c517db4c127d16b75e2f9b265caf33796b99fad4cd5f031b3</cites><orcidid>0000-0001-8942-9310</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1359644617303689$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29908265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pavan, Barbara</creatorcontrib><creatorcontrib>Dalpiaz, Alessandro</creatorcontrib><title>Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies</title><title>Drug discovery today</title><addtitle>Drug Discov Today</addtitle><description>•RPE epithelial barrier features play a key part in rethinopathies.•Adult human RPE cultured cells can express neuronal markers.•HRPE cells customized for tracking processes related to retinal diseases.•SVCT2, GLUTs, MRPs, OR51E2 are targets in cell-based therapies and drug delivery.•RARβ is a topic for renewal of retinal dopaminergic precursors in RPE cells.
Retinal pigment epithelium (RPE) is a cell monolayer essential for photoreceptor function and forming the blood–retinal barrier. RPE and retinal neurons share the same origin and a polarized cytoarchitecture. Several factors determine the phagocytosis and permeability of RPE, influencing photoreceptor renewal and drug delivery, efficacy and toxicity. Adult human RPE expresses neuronal markers in vitro, indicating a potential transdifferentiation. Degeneration of the RPE leads to death of photoreceptors and retinal neurons, resulting in the vision loss of retinopathy. 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Retinal pigment epithelium (RPE) is a cell monolayer essential for photoreceptor function and forming the blood–retinal barrier. RPE and retinal neurons share the same origin and a polarized cytoarchitecture. Several factors determine the phagocytosis and permeability of RPE, influencing photoreceptor renewal and drug delivery, efficacy and toxicity. Adult human RPE expresses neuronal markers in vitro, indicating a potential transdifferentiation. Degeneration of the RPE leads to death of photoreceptors and retinal neurons, resulting in the vision loss of retinopathy. Here, we suggest tools for cell engineering to discover new ways for activating the endogenous regeneration of barrier functions and/or of the retinal precursors in RPE cells.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29908265</pmid><doi>10.1016/j.drudis.2018.06.009</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8942-9310</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Ophthalmic Animals Cell Line Drug Delivery Systems Drug Discovery - methods Gene Expression Regulation Gene Transfer Techniques Genotype Humans Molecular Targeted Therapy Phenotype Retinal Diseases - genetics Retinal Diseases - metabolism Retinal Diseases - pathology Retinal Diseases - therapy Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Signal Transduction - drug effects |
| title | Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies |
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