Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker

Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44 /CD24 and ALDH1 breast cancer stem cells are enriched in TNBC and ma...

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Veröffentlicht in:	Biomarkers in medicine 2018-07, Vol.12 (7), p.813-820
Hauptverfasser:	O'Conor, Christopher J, Chen, Tiffany, González, Iván, Cao, Dengfeng, Peng, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	biomarkers Breast cancer cancer stem cells Cancer therapies CD44 antigen Chemoresistance Chemotherapy Dehydrogenases Gene expression Genotype & phenotype Ligands Medical diagnosis Medical prognosis Metastases Metastasis Mutation Nanoparticles Patients Stem cells Therapeutic targets triple-negative breast cancer Tumorigenesis Tumors
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