Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker
Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44 /CD24 and ALDH1 breast cancer stem cells are enriched in TNBC and ma...
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| Veröffentlicht in: | Biomarkers in medicine 2018-07, Vol.12 (7), p.813-820 |
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| creator | O'Conor, Christopher J Chen, Tiffany González, Iván Cao, Dengfeng Peng, Yan |
| description | Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44
/CD24
and ALDH1
breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC. This review highlights the current understanding of breast cancer stem cells in TNBC, with focus on CD44
/CD24
and ALDH1
breast cancer stem cells. It is our hope that this work provides insight into the potential role of cancer stem cells in the prognostication and therapeutic targeting of TNBC. |
| doi_str_mv | 10.2217/bmm-2017-0398 |
| format | Article |
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/CD24
and ALDH1
breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC. This review highlights the current understanding of breast cancer stem cells in TNBC, with focus on CD44
/CD24
and ALDH1
breast cancer stem cells. It is our hope that this work provides insight into the potential role of cancer stem cells in the prognostication and therapeutic targeting of TNBC.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2017-0398</identifier><identifier>PMID: 29902924</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>biomarkers ; Breast cancer ; cancer stem cells ; Cancer therapies ; CD44 antigen ; Chemoresistance ; Chemotherapy ; Dehydrogenases ; Gene expression ; Genotype & phenotype ; Ligands ; Medical diagnosis ; Medical prognosis ; Metastases ; Metastasis ; Mutation ; Nanoparticles ; Patients ; Stem cells ; Therapeutic targets ; triple-negative breast cancer ; Tumorigenesis ; Tumors</subject><ispartof>Biomarkers in medicine, 2018-07, Vol.12 (7), p.813-820</ispartof><rights>2018 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Jul 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-40fdee3c806453d19c069d5644cc28d236982b9026dc9a176e3a59b57a6ca0da3</citedby><cites>FETCH-LOGICAL-c371t-40fdee3c806453d19c069d5644cc28d236982b9026dc9a176e3a59b57a6ca0da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29902924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Conor, Christopher J</creatorcontrib><creatorcontrib>Chen, Tiffany</creatorcontrib><creatorcontrib>González, Iván</creatorcontrib><creatorcontrib>Cao, Dengfeng</creatorcontrib><creatorcontrib>Peng, Yan</creatorcontrib><title>Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44
/CD24
and ALDH1
breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC. This review highlights the current understanding of breast cancer stem cells in TNBC, with focus on CD44
/CD24
and ALDH1
breast cancer stem cells. It is our hope that this work provides insight into the potential role of cancer stem cells in the prognostication and therapeutic targeting of TNBC.</description><subject>biomarkers</subject><subject>Breast cancer</subject><subject>cancer stem cells</subject><subject>Cancer therapies</subject><subject>CD44 antigen</subject><subject>Chemoresistance</subject><subject>Chemotherapy</subject><subject>Dehydrogenases</subject><subject>Gene expression</subject><subject>Genotype & phenotype</subject><subject>Ligands</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Nanoparticles</subject><subject>Patients</subject><subject>Stem cells</subject><subject>Therapeutic targets</subject><subject>triple-negative breast cancer</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtLAzEURoMotlaXbiXgxs1oHjNJ406KLyi40Z0QMpnbkjqTqUlG8N-b2upCcJUbOPfjuwehU0ouGaPyqu66ghEqC8LVdA-NqaxYniXd_50FH6GjGFeEVFIKdohGTCnCFCvH6HVmvIWAY4IOW2jbiJ3HKbh1C4WHpUnuA3AdwMSE7Td7jQ1e9wl8cqbFyYQlJGx8g9ehX_o-JmdxZ8IbhGN0sDBthJPdO0Evd7fPs4di_nT_OLuZFzb3TEVJFg0At1Miyoo3VFkiVFOJsrSWTRvGhZqyOjcWjVWGSgHcVKqupBHWkMbwCbrY5uYG7wPEpDsXN8cYD_0QNSOV4IpKLjN6_gdd9UPwuZ3OOkVFiZAsU8WWsqGPMcBCr4PLN31qSjac1Fm73mjXG-2ZP9ulDnUHzS_94zkDagsshjQEiNZBVqm3v7zhrPPwT_gXZ4OQxA</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>O'Conor, Christopher J</creator><creator>Chen, Tiffany</creator><creator>González, Iván</creator><creator>Cao, Dengfeng</creator><creator>Peng, Yan</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20180701</creationdate><title>Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker</title><author>O'Conor, Christopher J ; Chen, Tiffany ; González, Iván ; Cao, Dengfeng ; Peng, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-40fdee3c806453d19c069d5644cc28d236982b9026dc9a176e3a59b57a6ca0da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>biomarkers</topic><topic>Breast cancer</topic><topic>cancer stem cells</topic><topic>Cancer therapies</topic><topic>CD44 antigen</topic><topic>Chemoresistance</topic><topic>Chemotherapy</topic><topic>Dehydrogenases</topic><topic>Gene expression</topic><topic>Genotype & phenotype</topic><topic>Ligands</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Nanoparticles</topic><topic>Patients</topic><topic>Stem cells</topic><topic>Therapeutic targets</topic><topic>triple-negative breast cancer</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Conor, Christopher J</creatorcontrib><creatorcontrib>Chen, Tiffany</creatorcontrib><creatorcontrib>González, Iván</creatorcontrib><creatorcontrib>Cao, Dengfeng</creatorcontrib><creatorcontrib>Peng, Yan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Conor, Christopher J</au><au>Chen, Tiffany</au><au>González, Iván</au><au>Cao, Dengfeng</au><au>Peng, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>12</volume><issue>7</issue><spage>813</spage><epage>820</epage><pages>813-820</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44
/CD24
and ALDH1
breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC. This review highlights the current understanding of breast cancer stem cells in TNBC, with focus on CD44
/CD24
and ALDH1
breast cancer stem cells. It is our hope that this work provides insight into the potential role of cancer stem cells in the prognostication and therapeutic targeting of TNBC.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>29902924</pmid><doi>10.2217/bmm-2017-0398</doi><tpages>8</tpages></addata></record> |
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| subjects | biomarkers Breast cancer cancer stem cells Cancer therapies CD44 antigen Chemoresistance Chemotherapy Dehydrogenases Gene expression Genotype & phenotype Ligands Medical diagnosis Medical prognosis Metastases Metastasis Mutation Nanoparticles Patients Stem cells Therapeutic targets triple-negative breast cancer Tumorigenesis Tumors |
| title | Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker |
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