2-Methoxyestradiol inhibits hypoxia-induced scleroderma fibroblast collagen synthesis by phosphatidylinositol 3-kinase/Akt/mTOR signalling

Abstract Objectives To investigate the mechanism of 2-methoxyestradiol (2-ME) in inhibiting hypoxia-induced collagen synthesis of fibroblasts in SSc. Methods The expressions of hypoxia-inducible factor 1 alpha (HIF-1α) and connective tissue growth factor (CTGF) in skin specimens derived from SSc pat...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2018-09, Vol.57 (9), p.1675-1684
Hauptverfasser:	Zhou, Xing, Liu, Chaofan, Lu, Jinghao, Zhu, Lubing, Li, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Apoptosis Caspase-3 Cell cycle Cell Proliferation Cells, Cultured Collagen Collagen (type I) Collagen Type I - biosynthesis Collagen Type I - drug effects Connective tissue growth factor Connective Tissue Growth Factor - biosynthesis Connective Tissue Growth Factor - drug effects Connective tissues Estradiol - analogs & derivatives Estradiol - pharmacology Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Flow cytometry Gene Expression Regulation Humans Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Hypoxia-inducible factor 1a Hypoxia-inducible factors Immunofluorescence Immunohistochemistry Kinases Proteins Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-akt - genetics Rapamycin RNA - genetics Scleroderma Scleroderma, Systemic - drug therapy Scleroderma, Systemic - genetics Scleroderma, Systemic - metabolism Signal Transduction Skin - metabolism Skin - pathology Systemic sclerosis TOR protein TOR Serine-Threonine Kinases - biosynthesis TOR Serine-Threonine Kinases - genetics Tubulin Modulators - pharmacology Western blotting
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