Annexin A3 Expression Increases in Hepatocytes and is Regulated by Hepatocyte Growth Factor in Rat Liver Regeneration
Annexin (Anx) A3 increases and plays important roles in the signalling cascade in hepatocyte growth in cultured hepatocytes. However, no information is available on its expression and role in rat liver regeneration. In the present study, AnxA3 expression was investigated to determine whether it also...
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| Veröffentlicht in: | Journal of biochemistry (Tokyo) 2008-04, Vol.143 (4), p.537-545 |
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| container_title | Journal of biochemistry (Tokyo) |
| container_volume | 143 |
| creator | Harashima, Mizuho Harada, Kayo Ito, Yoshimasa Hyuga, Masashi Seki, Taiichiro Ariga, Toyohiko Yamaguchi, Teruhide Niimi, Shingo |
| description | Annexin (Anx) A3 increases and plays important roles in the signalling cascade in hepatocyte growth in cultured hepatocytes. However, no information is available on its expression and role in rat liver regeneration. In the present study, AnxA3 expression was investigated to determine whether it also plays a role in the signalling cascade in rat liver regeneration. AnxA3 protein and mRNA level both increase in liver after administration of carbon tetrachloride (CCl4) or 70% partial hepatectomy. AnxA3 protein level increases in isolated parenchymal hepatocytes, but not in non-parenchymal liver cells, in these rat liver regeneration models. AnxA3 mRNA increases in hepatocytes after CCl4 administration. Anti-hepatocyte growth factor antibody suppresses this increase in AnxA3 mRNA level. These results demonstrate that AnxA3 expression increases in hepatocytes through a hepatocyte growth factor-mediated pathway in rat liver regeneration models, suggesting that AnxA3 plays an important role in the signalling cascade in rat liver regeneration. |
| doi_str_mv | 10.1093/jb/mvm248 |
| format | Article |
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However, no information is available on its expression and role in rat liver regeneration. In the present study, AnxA3 expression was investigated to determine whether it also plays a role in the signalling cascade in rat liver regeneration. AnxA3 protein and mRNA level both increase in liver after administration of carbon tetrachloride (CCl4) or 70% partial hepatectomy. AnxA3 protein level increases in isolated parenchymal hepatocytes, but not in non-parenchymal liver cells, in these rat liver regeneration models. AnxA3 mRNA increases in hepatocytes after CCl4 administration. Anti-hepatocyte growth factor antibody suppresses this increase in AnxA3 mRNA level. These results demonstrate that AnxA3 expression increases in hepatocytes through a hepatocyte growth factor-mediated pathway in rat liver regeneration models, suggesting that AnxA3 plays an important role in the signalling cascade in rat liver regeneration.</description><identifier>ISSN: 0021-924X</identifier><identifier>EISSN: 1756-2651</identifier><identifier>DOI: 10.1093/jb/mvm248</identifier><identifier>PMID: 18182385</identifier><language>eng</language><publisher>England: Japanese Biochemical Society</publisher><subject>Animals ; annexin A3 ; Annexin A3 - genetics ; Annexin A3 - metabolism ; Base Sequence ; carbon tetrachloride ; Carbon Tetrachloride - toxicity ; DNA Primers ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - physiology ; Hepatectomy ; hepatocyte growth factor ; Hepatocyte Growth Factor - physiology ; Hepatocytes - cytology ; Hepatocytes - drug effects ; Hepatocytes - metabolism ; Liver Regeneration ; Male ; parenchymal hepatocytes ; partial hepatectomy ; Rats ; Rats, Wistar ; RNA, Messenger - genetics ; Signal Transduction</subject><ispartof>Journal of biochemistry (Tokyo), 2008-04, Vol.143 (4), p.537-545</ispartof><rights>2008 The Japanese Biochemical Society. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-9bf42db8966f3f4804ff54bc4eb6ba73b6070bc64df08f6735102252561850b83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18182385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harashima, Mizuho</creatorcontrib><creatorcontrib>Harada, Kayo</creatorcontrib><creatorcontrib>Ito, Yoshimasa</creatorcontrib><creatorcontrib>Hyuga, Masashi</creatorcontrib><creatorcontrib>Seki, Taiichiro</creatorcontrib><creatorcontrib>Ariga, Toyohiko</creatorcontrib><creatorcontrib>Yamaguchi, Teruhide</creatorcontrib><creatorcontrib>Niimi, Shingo</creatorcontrib><title>Annexin A3 Expression Increases in Hepatocytes and is Regulated by Hepatocyte Growth Factor in Rat Liver Regeneration</title><title>Journal of biochemistry (Tokyo)</title><addtitle>J Biochem</addtitle><description>Annexin (Anx) A3 increases and plays important roles in the signalling cascade in hepatocyte growth in cultured hepatocytes. However, no information is available on its expression and role in rat liver regeneration. In the present study, AnxA3 expression was investigated to determine whether it also plays a role in the signalling cascade in rat liver regeneration. AnxA3 protein and mRNA level both increase in liver after administration of carbon tetrachloride (CCl4) or 70% partial hepatectomy. AnxA3 protein level increases in isolated parenchymal hepatocytes, but not in non-parenchymal liver cells, in these rat liver regeneration models. AnxA3 mRNA increases in hepatocytes after CCl4 administration. Anti-hepatocyte growth factor antibody suppresses this increase in AnxA3 mRNA level. These results demonstrate that AnxA3 expression increases in hepatocytes through a hepatocyte growth factor-mediated pathway in rat liver regeneration models, suggesting that AnxA3 plays an important role in the signalling cascade in rat liver regeneration.</description><subject>Animals</subject><subject>annexin A3</subject><subject>Annexin A3 - genetics</subject><subject>Annexin A3 - metabolism</subject><subject>Base Sequence</subject><subject>carbon tetrachloride</subject><subject>Carbon Tetrachloride - toxicity</subject><subject>DNA Primers</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - physiology</subject><subject>Hepatectomy</subject><subject>hepatocyte growth factor</subject><subject>Hepatocyte Growth Factor - physiology</subject><subject>Hepatocytes - cytology</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - metabolism</subject><subject>Liver Regeneration</subject><subject>Male</subject><subject>parenchymal hepatocytes</subject><subject>partial hepatectomy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - genetics</subject><subject>Signal Transduction</subject><issn>0021-924X</issn><issn>1756-2651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EokvhwB8AHxASh1B_xI5z3C5tt2IlpEJRxcWyk3HJsomD7ZTdf0-irIATp9FonveR5kXoJSXvKSn52daetQ8ty9UjtKCFkBmTgj5GC0IYzUqW352gZzFup5Vx_hSdUEUV40os0LDsOtg3HV5yfLHvA8TY-A5fd1UAEyHi8bSG3iRfHdK4mq7GTcQ3cD_sTIIa28M_d3wV_K_0HV-aKvkwZW9MwpvmAcIUgQ6CSaP_OXrizC7Ci-M8RbeXF19W62zz6ep6tdxkVS5kykrrclZbVUrpuMsVyZ0Tua1ysNKagltJCmIrmdeOKCcLLihhTDAhqRLEKn6K3s7ePvifA8Sk2yZWsNuZDvwQNSNCcl7yEXw3g1XwMQZwug9Na8JBU6KnjvXW6rnjkX11lA62hfoveSx1BN7MgB_6_3qyGWtigv0f0IQfenylEHp9902vxIqdf_34QU_a1zPvjNfmPjRR335mhHJCVFGUivDfGmScqA</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Harashima, Mizuho</creator><creator>Harada, Kayo</creator><creator>Ito, Yoshimasa</creator><creator>Hyuga, Masashi</creator><creator>Seki, Taiichiro</creator><creator>Ariga, Toyohiko</creator><creator>Yamaguchi, Teruhide</creator><creator>Niimi, Shingo</creator><general>Japanese Biochemical Society</general><general>Oxford University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope></search><sort><creationdate>20080401</creationdate><title>Annexin A3 Expression Increases in Hepatocytes and is Regulated by Hepatocyte Growth Factor in Rat Liver Regeneration</title><author>Harashima, Mizuho ; Harada, Kayo ; Ito, Yoshimasa ; Hyuga, Masashi ; Seki, Taiichiro ; Ariga, Toyohiko ; Yamaguchi, Teruhide ; Niimi, Shingo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-9bf42db8966f3f4804ff54bc4eb6ba73b6070bc64df08f6735102252561850b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>annexin A3</topic><topic>Annexin A3 - genetics</topic><topic>Annexin A3 - metabolism</topic><topic>Base Sequence</topic><topic>carbon tetrachloride</topic><topic>Carbon Tetrachloride - toxicity</topic><topic>DNA Primers</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - physiology</topic><topic>Hepatectomy</topic><topic>hepatocyte growth factor</topic><topic>Hepatocyte Growth Factor - physiology</topic><topic>Hepatocytes - cytology</topic><topic>Hepatocytes - drug effects</topic><topic>Hepatocytes - metabolism</topic><topic>Liver Regeneration</topic><topic>Male</topic><topic>parenchymal hepatocytes</topic><topic>partial hepatectomy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - genetics</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harashima, Mizuho</creatorcontrib><creatorcontrib>Harada, Kayo</creatorcontrib><creatorcontrib>Ito, Yoshimasa</creatorcontrib><creatorcontrib>Hyuga, Masashi</creatorcontrib><creatorcontrib>Seki, Taiichiro</creatorcontrib><creatorcontrib>Ariga, Toyohiko</creatorcontrib><creatorcontrib>Yamaguchi, Teruhide</creatorcontrib><creatorcontrib>Niimi, Shingo</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Journal of biochemistry (Tokyo)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harashima, Mizuho</au><au>Harada, Kayo</au><au>Ito, Yoshimasa</au><au>Hyuga, Masashi</au><au>Seki, Taiichiro</au><au>Ariga, Toyohiko</au><au>Yamaguchi, Teruhide</au><au>Niimi, Shingo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Annexin A3 Expression Increases in Hepatocytes and is Regulated by Hepatocyte Growth Factor in Rat Liver Regeneration</atitle><jtitle>Journal of biochemistry (Tokyo)</jtitle><addtitle>J Biochem</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>143</volume><issue>4</issue><spage>537</spage><epage>545</epage><pages>537-545</pages><issn>0021-924X</issn><eissn>1756-2651</eissn><abstract>Annexin (Anx) A3 increases and plays important roles in the signalling cascade in hepatocyte growth in cultured hepatocytes. However, no information is available on its expression and role in rat liver regeneration. In the present study, AnxA3 expression was investigated to determine whether it also plays a role in the signalling cascade in rat liver regeneration. AnxA3 protein and mRNA level both increase in liver after administration of carbon tetrachloride (CCl4) or 70% partial hepatectomy. AnxA3 protein level increases in isolated parenchymal hepatocytes, but not in non-parenchymal liver cells, in these rat liver regeneration models. AnxA3 mRNA increases in hepatocytes after CCl4 administration. Anti-hepatocyte growth factor antibody suppresses this increase in AnxA3 mRNA level. These results demonstrate that AnxA3 expression increases in hepatocytes through a hepatocyte growth factor-mediated pathway in rat liver regeneration models, suggesting that AnxA3 plays an important role in the signalling cascade in rat liver regeneration.</abstract><cop>England</cop><pub>Japanese Biochemical Society</pub><pmid>18182385</pmid><doi>10.1093/jb/mvm248</doi><tpages>9</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Animals annexin A3 Annexin A3 - genetics Annexin A3 - metabolism Base Sequence carbon tetrachloride Carbon Tetrachloride - toxicity DNA Primers Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Hepatectomy hepatocyte growth factor Hepatocyte Growth Factor - physiology Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Liver Regeneration Male parenchymal hepatocytes partial hepatectomy Rats Rats, Wistar RNA, Messenger - genetics Signal Transduction |
| title | Annexin A3 Expression Increases in Hepatocytes and is Regulated by Hepatocyte Growth Factor in Rat Liver Regeneration |
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