A new psoralen derivative with enlarged antiproliferative properties

The synthesis of a new pyridazino[4,3- h]psoralen and the biological evaluation are reported. Following our results with benzopsoralens as potent photochemotherapeutic agents, we report the antiproliferative evaluation of nitrogenated isoster upon and without UVA irradiation. The evaluated pyridazin...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-05, Vol.19 (10), p.2874-2876
Hauptverfasser:	Dalla Via, Lisa, González-Gómez, Jose Carlos, Pérez-Montoto, Lázaro Guillermo, Santana, Lourdes, Uriarte, Eugenio, Marciani Magno, Sebastiano, Gia, Ornella
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Antiproliferative activity Biological and medical sciences Cell Line Ficusin - chemical synthesis Ficusin - chemistry Ficusin - toxicity General aspects Guinea Pigs HeLa Cells Humans Medical sciences Methoxsalen - toxicity Pharmacology. Drug treatments Photobiology Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Pyridazines - chemical synthesis Pyridazines - chemistry Pyridazines - toxicity Pyridazinopsoralen Ultraviolet Rays
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