Hydroxamic Acid-Containing Hydrogels for Nonabsorbed Iron Chelation Therapy:  Synthesis, Characterization, and Biological Evaluation

Iron overload is a severe clinical condition and can be largely prevented by the use of iron-specific chelating agents. A successful iron chelator needs to be orally active, nontoxic, and selective. In this study, hydrogels containing pendant hydroxamic acid groups have been synthesized as potential...

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Veröffentlicht in:Biomacromolecules 2005-11, Vol.6 (6), p.2946-2953
Hauptverfasser: Polomoscanik, Steven C, Cannon, C. Pat, Neenan, Thomas X, Holmes-Farley, S. Randall, Mandeville, W. Harry, Dhal, Pradeep K
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Sprache:eng
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