In vivo confocal microscopy, an inner vision of the cornea - a major review

The demands of modern ophthalmology have evolved from descriptive findings from the slit lamp to in vivo assessment of cellular level changes. Nowadays, the latter can be provided by in vivo confocal microscopy. This article gives an overview of confocal principles using tandem scanning, scanning sl...

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Veröffentlicht in:Clinical & experimental ophthalmology 2009-01, Vol.37 (1), p.100-117
Hauptverfasser: Guthoff, Rudolf F, Zhivov, Andrey, Stachs, Oliver
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container_title Clinical & experimental ophthalmology
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creator Guthoff, Rudolf F
Zhivov, Andrey
Stachs, Oliver
description The demands of modern ophthalmology have evolved from descriptive findings from the slit lamp to in vivo assessment of cellular level changes. Nowadays, the latter can be provided by in vivo confocal microscopy. This article gives an overview of confocal principles using tandem scanning, scanning slit and laser scanning techniques used in ophthalmology. The main part of the paper describes the clinical applications emphasizing the anatomy of the normal and pathological cornea, and illustrates side‐effects of topical medication, contact lens wear, cross‐linking and refractive surgery. Finally, a summary about experimental applications, including animal studies, surface characterization and volume rendering as well as future developments, is given.
doi_str_mv 10.1111/j.1442-9071.2009.02016.x
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Administration, Topical
Animals
confocal microscopy
Contact Lenses - adverse effects
cornea
Cornea - anatomy & histology
Cornea - drug effects
Cornea - pathology
Corneal Diseases - pathology
Diagnosis, Differential
Humans
laser scanning
Microscopy, Confocal - classification
Microscopy, Confocal - methods
Microscopy, Confocal - trends
Mitomycin - administration & dosage
Mitomycin - adverse effects
Nucleic Acid Synthesis Inhibitors - administration & dosage
Nucleic Acid Synthesis Inhibitors - adverse effects
Postoperative Care
Preservatives, Pharmaceutical - adverse effects
Pterygium - surgery
Refractive Surgical Procedures - adverse effects
title In vivo confocal microscopy, an inner vision of the cornea - a major review
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