Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis

IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis...

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Veröffentlicht in:	International immunology 2008-02, Vol.20 (2), p.209-214
Hauptverfasser:	Yoshimura, Takeru, Sonoda, Koh-Hei, Miyazaki, Yoshiyuki, Iwakura, Yoichiro, Ishibashi, Tatsuro, Yoshimura, Akihiko, Yoshida, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Autoimmune Diseases - chemically induced Autoimmune Diseases - immunology Autoimmune Diseases - physiopathology autoimmunity CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism cytokines Cytokines - metabolism Eye Proteins - administration & dosage Eye Proteins - chemistry Eye Proteins - toxicity Humans inflammation Inflammation - immunology Inflammation - physiopathology Interferon-gamma - genetics Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-17 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Retinitis - chemically induced Retinitis - immunology Retinitis - physiopathology Retinol-Binding Proteins - administration & dosage Retinol-Binding Proteins - chemistry Retinol-Binding Proteins - toxicity Th1 Th1 Cells Th17 Uveitis - chemically induced Uveitis - immunology Uveitis - physiopathology
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