Giant condyloma acuminata of Buschke-Loewenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

Giant condyloma acuminata of Buschke-Loewenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

SummaryHuman papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carrie...

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Veröffentlicht in:Clinical and experimental dermatology 2009-04, Vol.34 (3), p.366-368
Hauptverfasser: Erkek, E, Basar, H, Bozdogan, O, Emeksiz, M C
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Sprache:eng
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Papillomavirus
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container_title Clinical and experimental dermatology
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creator Erkek, E
Basar, H
Bozdogan, O
Emeksiz, M C
description SummaryHuman papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of squamous cell carcinoma. Various treatments have been used, but response is often poor and recurrence rates high. We present a case of GCA successfully treated with a combination of surgical excision, oral acitretin and topical imiquimod. The diagnosis was based on histological examination, immunohistochemical analysis and in situ hybridization for HPV 6 and 11. We recommend a trial of oral retinoid and topical imiquimod in selected cases of GCA.
doi_str_mv 10.1111/j.1365-2230.2008.02938.x
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source Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Papillomavirus
title Giant condyloma acuminata of Buschke-Loewenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod
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